929890-64-2
929890-64-2
Chemical Structure
AZD-7295
- CAS No.: 929890-64-2
- Formula:C32H35F3N4O5S
- Molecular Weight:644.70
IUPAC Name: 5'-(cyclopropanecarboxamido)-N-(4-((4-(propylsulfonyl)piperazin-1-yl)methyl)phenyl)-2'-(trifluoromethoxy)-[1,1'-biphenyl]-4-carboxamide
InChIKey: MAQDQJWCSSCURR-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=CC(NC(C3CC3)=O)=CC=C2OC(F)(F)F)C=C1)NC4=CC=C(CN5CCN(S(=O)(CCC)=O)CC5)C=C4
Biological Activity: AZD-7295 is a HCV NS5A protein inhibitor, with an EC50 of 7 nM for GT-1b replicon[1][2].
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AZD-7295 | AZD-7295 is a HCV NS5A protein inhibitor, with an EC50 of 7 nM for GT-1b replicon. | |||||||||||||||||||||
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References
- [1]. Erik De Clercq, et al. Current race in the development of DAAs (direct-acting antivirals) against HCV. Biochem Pharmacol. 2014 Jun 15;89(4):441-52. [Content Brief]
- [2]. Min Gao, et al. Antiviral activity and resistance of HCV NS5A replication complex inhibitors. Curr Opin Virol. 2013 Oct;3(5):514-20. [Content Brief]
