929916-05-2
929916-05-2
Chemical Structure
DG051 free acid
- CAS No.: 929916-05-2
- Formula:C21H24ClNO4
- Molecular Weight:389.87
IUPAC Name: (S)-4-(2-((4-(4-chlorophenoxy)phenoxy)methyl)pyrrolidin-1-yl)butanoic acid
InChIKey: PVCTYSQBVIGZRU-KRWDZBQOSA-N
SMILES: ClC(C=C1)=CC=C1OC(C=C2)=CC=C2OC[C@H]3N(CCC3)CCCC(O)=O
Biological Activity: DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a Kd of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke[1][2].
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DG051 free acid | DG051 (free acid) is an effective inhibitor of leukotriene A4 hydrolase (LTA4H), with a Kd of 26 nM. It has high water solubility (greater than 30 mg/mL) and high oral bioavailability (over 80% across different species). DG051 (free acid) can be used in research related to myocardial infarction and stroke. | |||||||||||||||||||||
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References
- [1]. Enache L A, et al. Development of a scalable synthetic process for DG-051B, a First-in-Class inhibitior of LTA4H[J]. Organic Process Research & Development, 2009, 13(6): 1177-1184.
- [2]. Sandanayaka V, et al. Discovery of 4-[(2 S)-2-{[4-(4-chlorophenoxy) phenoxy] methyl}-1-pyrrolidinyl] butanoic acid (DG-051) as a novel leukotriene A4 hydrolase inhibitor of leukotriene B4 biosynthesis[J]. Journal of medicinal chemistry, 2010, 53(2): 573-585.
