930470-97-6
930470-97-6
Chemical Structure
DG70
Synonym(s): GSK1733953A
- CAS No.: 930470-97-6
- Formula:C21H17ClFNO3
- Molecular Weight:385.82
IUPAC Name: 2-chloro-N-(4',6-dimethoxy-[1,1'-biphenyl]-3-yl)-4-fluorobenzamide
InChIKey: RWSCJEILSRMTEH-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C2=CC=C(OC)C=C2)=C(OC)C=C1)C3=CC=C(F)C=C3Cl
Biological Activity: DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
DG70 | 99.70% | DG70 (GSK1733953A), a biphenyl amide, is a respiration inhibitor in Mycobacterium tuberculosis, inhibits MenG activity with an IC50 value of 2.6 ± 0.6 μM. DG70 inhibits the catalytic methylation of Mycobacterium tuberculosis demethylmenaquinone methyltransferase enzymes. DG70 can be used for Tuberculosis (TB) research. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
A-803467 | 99.69% | A-803467 is a potent and selective tetrodotoxin-resistant Nav1.8 sodium channel blocker (IC50=8 nM). A-803467 has shown significant anti-nociception in neuropathic and inflammatory pain models. A-803467 enhances the chemosensitivity of conventional anticancer agents through interaction with the ATP-binding cassette subfamily G member 2 (ABCG2) transporter. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Synta66 | 99.27% | Synta66 is an inhibitor of store-operated calcium entry channel Orai, which forms the pore of the CRAC channel, and used for the research of neurological disease. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CID 1375606 | 99.90% | CID 1375606 is a surrogate agonist of orphan G protein-coupled receptor GPR27. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
LY 189332 | LY 189332 is a potent antimetastatic agent. LY 189332 inhibits spontaneous lung metastasis. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
D159687 | 98.42% | D159687 is a selective PDE4D inhibitor. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
hPL-IN-1 | hPL-IN-1 (compound 2t) is a reversible inhibitor of pancreatic lipase (PL) (IC50=1.86 μM) for anti-obesity research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Sirtuin modulator 6 | 99.70% | Sirtuin modulator 6 (compound 262) increases the lifespan of a cell. Sirtuin modulator 6 can be used for study of diabetes, obesity, neurodegenerative diseases, cardiovascular disease, and so an extracted from patent WO2009064913A1. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
FFAR4 agonist-1 | FFAR4 agonist-1 is an orally active, selective agonist of FFAR4. FFAR4 agonist-1 improves glucose tolerance, reduces blood glucose levels and promotes insulin secretion. FFAR4 agonist-1 can be used in the research of type 2 diabetes. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
2',5'-Dimethoxy-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid | 2',5'-Dimethoxy-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid(4-[4-(4-Carboxyphenyl)-2,5-dimethoxyphenyl]benzoic acid) is a metal-organic framework (MOF). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
2,2''-Dimethoxy-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid | 2,2''-Dimethoxy-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid is a metal-organic framework (MOF). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Pujari V, et al. Mycobacterial MenG: Partial Purification, Characterization, and Inhibition. ACS Infect Dis. 2022 Dec 9;8(12):2430-2440. [Content Brief]
- [2]. Adewumi AT, et al. Thompson loop: opportunities for antitubercular drug design by targeting the weak spot in demethylmenaquinone methyltransferase protein. RSC Adv. 2020 Jun 19;10(39):23466-23483. [Content Brief]
- [3]. Sukheja P, et al. A Novel Small-Molecule Inhibitor of the Mycobacterium tuberculosis Demethylmenaquinone Methyltransferase MenG Is Bactericidal to Both Growing and Nutritionally Deprived Persister Cells. mBio. 2017 Feb 14;8(1):e02022-16. [Content Brief]
