93117-08-9
93117-08-9
Chemical Structure
5-AIQ
Synonym(s): 5-Aminoisoquinolin-1-one
- CAS No.: 93117-08-9
- Formula:C9H8N2O
- Molecular Weight:160.18
IUPAC Name: 5-aminoisoquinolin-1(2H)-one
InChIKey: SVASVGVAQIVSEZ-UHFFFAOYSA-N
SMILES: O=C1NC=CC2=C1C=CC=C2N
Biological Activity: 5-AIQ (5-Aminoisoquinolin-1-one) is a PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5-AIQ | 99.75% | 5-AIQ (5-Aminoisoquinolin-1-one) is a PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver. | ||||||||||||||||||||
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5-AIQ (Standard) | ≥98% | 5-AIQ (5-Aminoisoquinolin-1-one) is a PARP-1 inhibitor. 5-AIQ is an important functional group in various drugs. 5-AIQ reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver. | ||||||||||||||||||||
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8-Chloroquinazolin-4-ol | 98.44% | 8-Chloroquinazolin-4-ol is a poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor with an IC50 value of 5.65 μM. 8-Chloroquinazolin-4-ol can be used in cancer-related research. | ||||||||||||||||||||
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Luminol | 99.91% | Luminol is a chemical that exhibits chemiluminescence with pKa values of 6.74 and 15.1. Luminol exhibits chemiluminescence (CL) at 425 nm λmax. Luminol is commonly used in forensics as a diagnostic tool for the detection of blood stains. | ||||||||||||||||||||
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8-Chloroisoquinolin-3(2H)-one | 96.93% | 8-Chloroisoquinolin-3(2H)-one is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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5-Amino-8-hydroxyquinoline | 95.0% | 5-Amino-8-hydroxyquinoline (5A8HQ; 5AHQ) is an orally active non-competitive 20S proteasome inhibitor. 5-Amino-8-hydroxyquinoline can inhibit NF-κB activity and induce cancer cells death and shows low cytotoxicity towards normal hematopoietic cells. 5-Amino-8-hydroxyquinoline can be used for the research of cancer, such as leukemia. | ||||||||||||||||||||
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1(2H)-Isoquinolinone | 99.67% | 1-Hydroxyisoquinoline is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | ||||||||||||||||||||
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5-AIQ hydrochloride | 5-AIQ hydrochloride is a PARP-1 inhibitor. 5-AIQ hydrochloride is an important functional group in various drugs. 5-AIQ hydrochloride reduces the tissue injury associated with ischemia-reperfusion of the liver, it can be used for the research of the research conditions associated with ischemia-reperfusion of the liver. | |||||||||||||||||||||
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1,5-Naphthalenediamine | 1,5-Naphthalenediamine is a naphthalene derivative. 1,5-Naphthalenediamine serves as a substrate for the detection and identification of trace molecules. | |||||||||||||||||||||
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1,5-Isoquinolinediol (Standard) | ≥98% | 1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC50 of 0.18-0.37 μM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina. | ||||||||||||||||||||
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4(3H)-Quinazolinone | 99.89% | 4(3H) -quinazolinone is a fused nitrogen heterocyclic compound whose derivatives have a wide range of antimicrobial and antitumor activities. | ||||||||||||||||||||
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Chloroxoquinoline | Chloroxoquinoline is an anticancer agent. Chloroxoquinoline damages the DNA templates of cancer cells, inducing DNA breaks and cell death, and inhibits cell invasion via down-regulating Rho/Rho kinase signaling pathway. Chloroxoquinoline enhances the radiation sensitivity of Lewis lung cancer cells and xenograft tumors in tumor-bearing mouse models but decreases efficacy after long term exposure in rat models by auto-induction effects on CYP1A and CYP3A. Chloroxoquinoline has a broad-spectrum anticancer activity, such as non-small-cell lung carcinoma (NSCLC), breast cancer and gastric cancer. | |||||||||||||||||||||
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References
- [1]. Vinod KR, Chandra S, Sharma SK. Evaluation of 5-aminoisoquinoline (5-AIQ), a novel PARP-1 inhibitor for genotoxicity potential in vitro and in vivo. Toxicol Mech Methods. 2010 Feb;20(2):90-5. [Content Brief]
- [2]. Mota-Filipe H, et al. The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat. Med Sci Monit. 2002 Nov;8(11):BR444-53. [Content Brief]
