934-00-9
Chemical Structure
3-Methoxycatechol
- CAS No.: 934-00-9
- Formula:C7H8O3
- Molecular Weight:140.14
IUPAC Name: 3-methoxybenzene-1,2-diol
InChIKey: LPYUENQFPVNPHY-UHFFFAOYSA-N
SMILES: COC1=CC=CC(=C1O)O
Biological Activity: 3-Methoxycatechol is a catechol derivative with endothelium-dependent vasodilatory and antihypertensive activities. 3-Methoxycatechol activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. 3-Methoxycatechol inhibits tau self-interaction and scavenges free radicals such as DPPH. 3-Methoxycatechol combined with NaNO2 enhances forestomach proliferative lesions and papilloma formation, reduces glandular stomach lesions, and promotes esophageal lesion development. 3-Methoxycatechol can be used for research related to hypertension and papilloma[1][2][3][4][5][6][7][8].
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3-Methoxycatechol | 99.98% | 3-Methoxycatechol is a catechol derivative with endothelium-dependent vasodilatory and antihypertensive activities. 3-Methoxycatechol activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. 3-Methoxycatechol inhibits tau self-interaction and scavenges free radicals such as DPPH. 3-Methoxycatechol combined with NaNO2 enhances forestomach proliferative lesions and papilloma formation, reduces glandular stomach lesions, and promotes esophageal lesion development. 3-Methoxycatechol can be used for research related to hypertension and papilloma. | ||||||||||||||||||||
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3-Methoxycatechol (Standard) | 99.34% | 3-Methoxycatechol (Standard) is the analytical standard of 3-Methoxycatechol (HY-W116576). This product is intended for research and analytical applications. 3-Methoxycatechol is a catechol derivative with endothelium-dependent vasodilatory and antihypertensive activities. 3-Methoxycatechol activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. 3-Methoxycatechol inhibits tau self-interaction and scavenges free radicals such as DPPH. 3-Methoxycatechol combined with NaNO2 enhances forestomach proliferative lesions and papilloma formation, reduces glandular stomach lesions, and promotes esophageal lesion development. 3-Methoxycatechol can be used for research related to hypertension and papilloma. | ||||||||||||||||||||
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References
- [1]. Dias P, et al. 3-methoxycatechol causes vasodilation likely via K channels: ex vivo, in silico docking and in vivo study. Vascular pharmacology. 2024 Sep;156:107418.
- [2]. Ma N, et al. NanoBiT screening identifies the azaoxafluorene VT11 as potent tau interaction inhibitor. Scientific reports. 2026 Aug 04;16(1):24013.
- [3]. Salam R. Structure-Based Drug Discovery: Computational Insights into TGR5 Agonists and Substituted Catechol Vasodilators[J]. 2025.
- [4]. Deng H, et al. The Three Catecholics Benserazide, Catechol and Pyrogallol are GPR35 Agonists. Pharmaceuticals (Basel, Switzerland). 2013 Apr 08;6(4):500-9.
- [5]. Bortolomeazzi R, et al. Comparative evaluation of the antioxidant capacity of smoke flavouring phenols by crocin bleaching inhibition, DPPH radical scavenging and oxidation potential[J]. Food chemistry, 2007, 100(4): 1481-1489.
- [6]. Tao Y, et al. Altering toluene 4-monooxygenase by active-site engineering for the synthesis of 3-methoxycatechol, methoxyhydroquinone, and methylhydroquinone. Journal of bacteriology. 2004 Jul;186(14):4705-13. [Content Brief]
- [7]. Hirose M, et al. Effects of sodium nitrite and catechol, 3-methoxycatechol, or butylated hydroxyanisole in combination in a rat multiorgan carcinogenesis model. Cancer research. 1993 Jan 01;53(1):32-7. [Content Brief]
- [8]. Ito N, et al. Carcinogenicity and modification of carcinogenic response by plant phenols[J]. 1992.
