936626-07-2
936626-07-2
Chemical Structure
MK-7288
- CAS No.: 936626-07-2
- Formula:C22H31N3O4
- Molecular Weight:401.50
IUPAC Name: (1r,4r)-2'-methoxy-N-methyl-7'-oxo-N-(2-(piperidin-1-yl)ethyl)-7'H-spiro[cyclohexane-1,5'-furo[3,4-b]pyridine]-4-carboxamide
InChIKey: QTAKNJDNFNDYPP-CIEDQVTBSA-N
SMILES: O=C([C@@H]1CC[C@]2(C3=CC=C(OC)N=C3C(O2)=O)CC1)N(C)CCN4CCCCC4
Biological Activity: MK-7288 is a histamine H3 receptor inverse agonist. MK-7288 can prolong sleep latency in the Maintain Wake Test (MWT). MK-7288 can be used in research on obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS)[1][2].
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MK-7288 | MK-7288 is a histamine H3 receptor inverse agonist. MK-7288 can prolong sleep latency in the Maintain Wake Test (MWT). MK-7288 can be used in research on obstructive sleep apnea (OSA) and excessive daytime sleepiness (EDS). | |||||||||||||||||||||
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References
- [1]. Sun H, et al. Early-stage comparative effectiveness: randomized controlled trial with histamine inverse agonist MK-7288 in excessive daytime sleepiness patients. J Clin Pharmacol. 2013 Dec;53(12):1294-302. [Content Brief]
- [2]. Neshat SS, et al. Evaluating pharmacological treatments for excessive daytime sleepiness in obstructive sleep apnea: A comprehensive network meta-analysis and systematic review. Sleep Med Rev. 2024 Aug;76:101934. [Content Brief]
