937245-42-6
Chemical Structure
Florbenazine
Synonym(s): AV-133
- CAS No.: 937245-42-6
- Formula:C21H32FNO3
- Molecular Weight:365.48
IUPAC Name: (2R,3R,11bR)-9-(3-fluoropropoxy)-3-isobutyl-10-methoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
InChIKey: GNKGXQHHUUEYQV-BHIYHBOVSA-N
SMILES: COC1=C(OCCCF)C=C2CCN(C[C@H]([C@@H](C3)O)CC(C)C)[C@@]3([H])C2=C1
Biological Activity: Florbenazine (AV-133) is a diagnostic imaging agent targeting the central nervous system monoamine transporter VMAT2, and its F-18 labeled form can be used for PET scanning. The biodistribution of [18F]Florbenazine in mice shows a high striatum/cerebellum ratio (0.48), which can be used for the diagnostic research of neurodegenerative diseases (including dementia with Lewy bodies and Parkinson's disease)[1].
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Florbenazine | Florbenazine (AV-133) is a diagnostic imaging agent targeting the central nervous system monoamine transporter VMAT2, and its F-18 labeled form can be used for PET scanning. The biodistribution of [18F]Florbenazine in mice shows a high striatum/cerebellum ratio (0.48), which can be used for the diagnostic research of neurodegenerative diseases (including dementia with Lewy bodies and Parkinson's disease). | |||||||||||||||||||||
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