937812-80-1
937812-80-1
Chemical Structure
gamma-Secretase Modulators
Synonym(s): Amyloid-β production inhibitor; γ-Secretase Modulators
- CAS No.: 937812-80-1
- Formula:C26H24F3N3O3
- Molecular Weight:483.48
IUPAC Name: (4R,9aS)-7-((E)-3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzylidene)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6(1H)-one
InChIKey: VHNYOQKVZQVBLC-RTCGXNAVSA-N
SMILES: O=C1N2[C@@H](COC[C@]2([H])CC/C1=C\C3=CC(OC)=C(C=C3)N4C=NC(C)=C4)C5=CC(F)=C(F)C(F)=C5
Biological Activity:
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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gamma-Secretase Modulators | 99.84% | gamma-Secretase Modulators (Amyloid-β production inhibitor) is a Amyloid-β production inhibitor. | ||||||||||||||||||||
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References
- Watahiki H, Yagishita S, Futai E, Ishiura S.CTF1-51, a truncated carboxyl-terminal fragment of amyloid precursor protein, suppresses the effects of Aβ42-lowering γ-secretase modulators.Neurosci Lett. 2012 Sep 27;526(2):96-9. Epub 2012 Aug 23. [Content Brief]
- Wanngren J, Ottervald J, Parpal S, Portelius E, Str?mberg K, Borgeg?rd T, Klintenberg R, Juréus A, Blomqvist J, Blennow K, Zetterberg H, Lundkvist J, Rosqvist S, Karlstr?m H.Second generation γ-secretase modulators exhibit different modulation of Notch β [Content Brief]
- Wagner SL, Tanzi RE, Mobley WC, Galasko D.Potential Use of γ-Secretase Modulators in the Treatment of Alzheimer Disease.Arch Neurol. 2012 Jul 16:1-4. [Content Brief]
- Bulic B, Ness J, Hahn S, Rennhack A, Jumpertz T, Weggen S.Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease.Curr Neuropharmacol. 2011 Dec;9(4):598-622. [Content Brief]
- Kretner, Benedikt; Fukumori, Akio; Gutsmiedl, Amelie; Page, Richard M.; Luebbers, Thomas; Galley, Guido; Baumann, Karlheinz; Haass, Christian; Steiner, Harald. Attenuated A.beta.42 Responses to Low Potency .gamma.-Secretase Modulators Can Be Overcome for
