937820-89-8
Chemical Structure
JC2-11
- CAS No.: 937820-89-8
- Formula:C17H15FO4
- Molecular Weight:302.30
IUPAC Name: (E)-1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one
InChIKey: YYAIFDXWRNNHAW-ZZXKWVIFSA-N
SMILES: COC1=CC(/C=C/C(C2=CC(F)=C(C=C2)OC)=O)=CC=C1O
Biological Activity: JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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JC2-11 | 98.03% | JC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1. | ||||||||||||||||||||
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