942619-79-6
942619-79-6
Chemical Structure
Tolvaptan phosphate ester sodium
- CAS No.: 942619-79-6
- Formula:C26H24ClN2Na2O6P
- Molecular Weight:572.88
InChIKey: IHNKFKPPZJVMMZ-UHFFFAOYSA-L
SMILES: O=C(C1=C(C)C=CC=C1)NC2=CC=C(C(C)=C2)C(N3C4=CC=C(C=C4C(CCC3)OP(O[Na])(O[Na])=O)Cl)=O
Biological Activity: Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation[1][2].
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Tolvaptan phosphate ester sodium | 99.85% | Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP)-induced platelet aggregation. | ||||||||||||||||||||
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References
- [1]. Hiroyuki Fujiki, et al. In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan. J Pharmacol Sci. 2022 Nov;150(3):163-172. [Content Brief]
- [2]. Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95(4):324-36. [Content Brief]
