942936-75-6
Chemical Structure
Phen-DC3
- CAS No.: 942936-75-6
- Formula:C34H26N6O2
- Molecular Weight:550.61
IUPAC Name: 3,3'-((1,10-phenanthroline-2,9-dicarbonyl)bis(azanediyl))bis(1-methylquinolin-1-ium)
InChIKey: CTOLNXAGCUTHBW-UHFFFAOYSA-P
SMILES: C[N+]1=C2C=CC=CC2=CC(NC(C3=CC=C4C=CC5=CC=C(C(NC6=C[N+](C)=C7C=CC=CC7=C6)=O)N=C5C4=N3)=O)=C1
Biological Activity: Phen-DC3 is a bisquinolinium G-quadruplex (G4) ligand. Phen-DC3 selectively binds to and stabilizes the hybrid quadruplex-duplex hybrid (QDH) derived from the PIM1 promoter. Phen-DC3 also binds to the c-myc promoter Pu24T G4 via extensive π-stacking, and induces polymerase stalling at α-synuclein DNA and RNA G4 sequences. Phen-DC3 Trifluoromethanesulfonate (HY-15594A) downregulates LPS (HY-D1056)-induced TNFRSF21, RIPK3 and p-MLKL in VECs, and ameliorates CLP-induced pulmonary vascular leakage in septic rats. Phen-DC3 can be used in studies related to neurodegenerative diseases and sepsis-associated vascular injury[1][2][3][4].
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Phen-DC3 | Phen-DC3 is a bisquinolinium G-quadruplex (G4) ligand. Phen-DC3 selectively binds to and stabilizes the hybrid quadruplex-duplex hybrid (QDH) derived from the PIM1 promoter. Phen-DC3 also binds to the c-myc promoter Pu24T G4 via extensive π-stacking, and induces polymerase stalling at α-synuclein DNA and RNA G4 sequences. Phen-DC3 Trifluoromethanesulfonate (HY-15594A) downregulates LPS (HY-D1056)-induced TNFRSF21, RIPK3 and p-MLKL in VECs, and ameliorates CLP-induced pulmonary vascular leakage in septic rats. Phen-DC3 can be used in studies related to neurodegenerative diseases and sepsis-associated vascular injury. | |||||||||||||||||||||
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References
- [1]. Ghosh A, et al. Structural basis of bis-quinolinium ligands binding to quadruplex-duplex hybrids from PIM1 oncogene. Nucleic acids research. 2025 Sep 05;53(17):gkaf894. [Content Brief]
- [2]. Turcotte MA, et al. Pathogenic SNPs Affect Both RNA and DNA G-Quadruplexes' Responses to Ligands. ACS chemical biology. 2024 May 17;19(5):1045-1050. [Content Brief]
- [3]. Chung WJ, et al. Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC(3). Angewandte Chemie (International ed. in English). 2014 Jan 20;53(4):999-1002. [Content Brief]
- [4]. Wang J, et al. The role and mechanism of TNFRSF21 in promoting necroptosis of vascular endothelial cells and inducing vascular leakage in sepsis. Journal of molecular medicine (Berlin, Germany). 2026 Apr 23;104(1):68. [Content Brief]
