942999-61-3
Chemical Structure
DGAT-1 inhibitor 2
- CAS No.: 942999-61-3
- Formula:C24H28N4O3
- Molecular Weight:420.50
IUPAC Name: 2-(4-(4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl)bicyclo[2.2.2]octan-1-yl)acetic acid
InChIKey: VGPKUACRBMPJLF-UHFFFAOYSA-N
SMILES: O=C(O)CC12CCC(CC1)(CC2)C3=CC=C(C=C3)C4=NC5=C(N)N=CN=C5OC4(C)C
Biological Activity: DGAT-1 inhibitor 2 is an orally active DGAT-1 inhibitor with IC50 values of 15 nM and 9 nM for human DGAT-1 and rat DGAT-1, respectively. DGAT-1 inhibitor 2 increases ROS concentration, GRP78, and PERK protein abundance. DGAT-1 inhibitor 2 increases SREBF1, CPT1A, and MTTP mRNA in fatty acid-treated cells. DGAT-1 inhibitor 2 improves obesity[1][2].
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DGAT-1 inhibitor 2 | 95.33% | DGAT-1 inhibitor 2 is an orally active DGAT-1 inhibitor with IC50 values of 15 nM and 9 nM for human DGAT-1 and rat DGAT-1, respectively. DGAT-1 inhibitor 2 increases ROS concentration, GRP78, and PERK protein abundance. DGAT-1 inhibitor 2 increases SREBF1, CPT1A, and MTTP mRNA in fatty acid-treated cells. DGAT-1 inhibitor 2 improves obesity. | ||||||||||||||||||||
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DGAT-1 inhibitor 2 (Standard) | ≥98% | DGAT-1 inhibitor 2 (Standard) is the analytical standard of DGAT-1 inhibitor 2 (HY-50670). This product is intended for research and analytical applications. DGAT-1 inhibitor 2 is an orally active DGAT-1 inhibitor with IC50 values of 15 nM and 9 nM for human DGAT-1 and rat DGAT-1, respectively. DGAT-1 inhibitor 2 increases ROS concentration, GRP78, and PERK protein abundance. DGAT-1 inhibitor 2 increases SREBF1, CPT1A, and MTTP mRNA in fatty acid-treated cells. DGAT-1 inhibitor 2 improves obesity. | ||||||||||||||||||||
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References
- [1]. Yang W, et al. Role of diacylglycerol O-acyltransferase (DGAT) isoforms in bovine hepatic fatty acid metabolism. J Dairy Sci. 2022 Apr;105(4):3588-3600. [Content Brief]
- [2]. Birch AM, et al. Discovery of a potent, selective, and orally efficacious pyrimidinooxazinyl bicyclooctaneacetic acid diacylglycerol acyltransferase-1 inhibitor. J Med Chem. 2009 Mar 26;52(6):1558-68. [Content Brief]
