943250-95-1
Chemical Structure
LK-980
- CAS No.: 943250-95-1
- Formula:C19H25N3O
- Molecular Weight:311.43
IUPAC Name: 2-(4-phenethylpiperazin-1-yl)-1-(pyridin-3-yl)ethan-1-ol
InChIKey: CTBNLHFXMNLQNE-UHFFFAOYSA-N
SMILES: OC(C=1C=NC=CC1)CN2CCN(CCC=3C=CC=CC3)CC2
Biological Activity: LK-980 is a cholesterol biosynthesis inhibitor. LK-980 primarily inhibits human sterol Δ7-reductase (DHCR7), and more weakly inhibits sterol Δ14-reductase (DHCR14), sterol Δ24-reductase (DHCR24), and sterol C5-desaturase (SC5DL). LK-980 is slowly metabolized in human primary hepatocytes and does not induce CYP3A4 enzyme activity or mRNA expression. LK-980 can be used in research related to cholesterol metabolism disorders such as hyperlipidemia and atherosclerosis, as well as cardiovascular diseases[1].
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LK-980 | LK-980 is a cholesterol biosynthesis inhibitor. LK-980 primarily inhibits human sterol Δ7-reductase (DHCR7), and more weakly inhibits sterol Δ14-reductase (DHCR14), sterol Δ24-reductase (DHCR24), and sterol C5-desaturase (SC5DL). LK-980 is slowly metabolized in human primary hepatocytes and does not induce CYP3A4 enzyme activity or mRNA expression. LK-980 can be used in research related to cholesterol metabolism disorders such as hyperlipidemia and atherosclerosis, as well as cardiovascular diseases. | |||||||||||||||||||||
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