945400-24-8
Chemical Structure
AZD-2184
- CAS No.: 945400-24-8
- Formula:C13H11N3OS
- Molecular Weight:257.31
IUPAC Name: 2-(6-(methylamino)pyridin-3-yl)benzo[d]thiazol-6-ol
InChIKey: FYTAUNFPOYWHBC-UHFFFAOYSA-N
SMILES: OC1=CC=C2N=C(SC2=C1)C=3C=NC(=CC3)NC
Biological Activity: AZD-2184 is a β-amyloid (Aβ(1-40)) fibril binder with blood-brain barrier permeability, exhibiting a Kd of 8.4 nM for hAβ(1-40). AZD-2184 binds to the same site as CPIB, shows low levels of non-specific binding to brain tissue, rapidly enters and clears from the brain tissue of normal rats, and binds reversibly to plaques in vivo. The radiolabeled form of AZD-2184 can serve as a PET ligand for the visualization of Aβ deposits. AZD-2184 is applicable to research related to Alzheimer's disease[1][2][3].
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AZD-2184 | AZD-2184 is a β-amyloid (Aβ(1-40)) fibril binder with blood-brain barrier permeability, exhibiting a Kd of 8.4 nM for hAβ(1-40). AZD-2184 binds to the same site as CPIB, shows low levels of non-specific binding to brain tissue, rapidly enters and clears from the brain tissue of normal rats, and binds reversibly to plaques in vivo. The radiolabeled form of AZD-2184 can serve as a PET ligand for the visualization of Aβ deposits. AZD-2184 is applicable to research related to Alzheimer's disease. | |||||||||||||||||||||
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References
- [1]. Johnson AE, et al. AZD2184: a radioligand for sensitive detection of beta-amyloid deposits. Journal of neurochemistry. 2009 Mar;108(5):1177-86. [Content Brief]
- [2]. Mattsson P, et al. β-Amyloid binding in elderly subjects with declining or stable episodic memory function measured with PET and [¹¹C]AZD2184. European journal of nuclear medicine and molecular imaging. 2015 Sep;42(10):1507-11. [Content Brief]
- [3]. Murugan NA, et al. The Culprit Is in the Cave: The Core Sites Explain the Binding Profiles of Amyloid-Specific Tracers. The journal of physical chemistry letters. 2016 Sep 01;7(17):3313-21. [Content Brief]
