945526-43-2
945526-43-2
Chemical Structure
ISCK03
- CAS No.: 945526-43-2
- Formula:C19H21N3O2S
- Molecular Weight:355.45
IUPAC Name: N-(4-(1H-imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide
InChIKey: XQABBHBFHWHMKF-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=CC=C(N3C=CN=C3)C=C2)=O
Biological Activity: ISCK03 is a SCF/c-Kit and CD117-specific inhibitor. ISCK03 significantly inhibits c-Kit phosphorylation at 10 μM[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ISCK03 | 98.30% | ISCK03 is a SCF/c-Kit and CD117-specific inhibitor. ISCK03 significantly inhibits c-Kit phosphorylation at 10 μM. | ||||||||||||||||||||
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References
- [1]. Wintzell M, et al. Repeated cisplatin treatment can lead to a multiresistant tumor cell population with stem cell features and sensitivity to 3-bromopyruvate. Cancer Biol Ther. 2012 Dec;13(14):1454-62. [Content Brief]
- [2]. Na YJ, et al. [4-t-butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide (ISCK03) inhibits SCF/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. Biochem Pharmacol. 2007 Sep 1;74(5):780-6. [Content Brief]
- [3]. Hirano T, et al. Long noncoding RNA, CCDC26, controls myeloid leukemia cell growth through regulation of KIT expression. Mol Cancer. 2015 Apr 19;14:90. doi: 10.1186/s12943-015-0364-7. [Content Brief]
