946002-48-8
946002-48-8
Chemical Structure
Hedgehog agonist 1
- CAS No.: 946002-48-8
- Formula:C29H28ClF2N3O2S
- Molecular Weight:556.07
IUPAC Name: 3-chloro-4,7-difluoro-N-(2-methoxy-5-(pyridin-4-yl)benzyl)-N-((1r,4r)-4-(methylamino)cyclohexyl)benzo[b]thiophene-2-carboxamide
InChIKey: YVIFQUJDZSAFKG-MEMLXQNLSA-N
SMILES: O=C(C1=C(Cl)C2=C(F)C=CC(F)=C2S1)N(CC3=CC(C4=CC=NC=C4)=CC=C3OC)[C@H]5CC[C@H](NC)CC5
Biological Activity: Hedgehog agonist 1 is a Hedgehog agonist that activates Hedgehog signaling by binding to Smoothened. Hedgehog agonist 1 can be used for research on stroke[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Hedgehog agonist 1 | 98.78% | Hedgehog agonist 1 is a Hedgehog agonist that activates Hedgehog signaling by binding to Smoothened. Hedgehog agonist 1 can be used for research on stroke. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CCG-232601 | 99.00% | CCG-232601 (compound 8f) is a potent and orally active Rho/MRTF/SRF transcriptional pathway inhibitor. CCG-232601 inhibits the development of Bleomycin-induced dermal fibrosis in mice. CCG-232601 has the potential for the research of antifibrotic for systemic scleroderma. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CP-447697 | 99.70% | CP-447697 is a lipophilic C5a receptor antagonist with an IC50 value of 31 nM. CP-447697 can be used for the research of inflammation. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Hh-Ag1.5 | 99.90% | Hh-Ag1.5 (SAg1.5) is a potent Hedgehog (Hh) agonist with an EC50 of 1 nM. Hh-Ag1.5 mediated reprogramming breaks the quiescence of noninjured liver stem cells for rescuing liver failure. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
(Rac)-SAG | (Rac)-SAG is an isoform of SAG (HY-12848). SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
SAG hydrochloride | 99.91% | SAG hydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG hydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
SAG dihydrochloride | 98.23% | SAG dihydrochloride is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG dihydrochloride activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
SAG (GMP) | SAG (GMP) is SAG (HY-12848) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. SAG is a potent Smoothened (Smo) receptor agonist (EC50=3 nM; Kd=59 nM). SAG activates the Hedgehog signaling pathway and counteracts Cyclopamine (HY-17024) inhibition of Smo. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
FAK inhibitor 6 | Compound 26F not only optimized the effective inhibitory enzyme (ic50= 28.2 nm), but also showed relatively less cytotoxicity (ic50= 3.32 μ M) And induced MDA-MB-231 cell apoptosis in a dose-dependent manner, effectively blocking MDA-MB-231 cells in g0/g1 phase. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
MRTF/SRF-IN-1 | 99.75% | MRTF/SRF-IN-1 (example 41) is an inhibitor of both myocardin-related transcription factor and serum response factor (MRTF/SRF). MRTF/SRF-IN-1 can be used for research for preventing cancer and fibrosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
SAG analog (cis-isomer) | SAG analog (cis-isomer) (SAG-Cl (cis-isomer)) (Compound 10b) is a Gli1 activator with an EC50 of 7.6 nM. SAG analog (cis-isomer) is non-toxic. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
