946249-82-7
946249-82-7
Chemical Structure
CU239
- CAS No.: 946249-82-7
- Formula:C19H15F3N4O3S
- Molecular Weight:436.41
IUPAC Name: 2-(2-(3-phenylureido)thiazol-4-yl)-N-(4-(trifluoromethoxy)phenyl)acetamide
InChIKey: UIWWYKGFNZZCQB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(OC(F)(F)F)C=C1)CC2=CSC(NC(NC3=CC=CC=C3)=O)=N2
Biological Activity: CU239 is a potent and competitive non-retinoic acid inhibitor of RPE65 with an IC50 for RPE65 isomerase (11-cis retinal) of 6 μM. CCU239 exhibits delayed chromophore regeneration after light bleach, and conferrs a partial protection of the retina against injury from high intensity light. CU239 can be used for the study of retinal degeneration[1].
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CU239 | CU239 is a potent and competitive non-retinoic acid inhibitor of RPE65 with an IC50 for RPE65 isomerase (11-cis retinal) of 6 μM. CCU239 exhibits delayed chromophore regeneration after light bleach, and conferrs a partial protection of the retina against injury from high intensity light. CU239 can be used for the study of retinal degeneration. | |||||||||||||||||||||
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