946305-51-7
946305-51-7
Chemical Structure
MFT251
- CAS No.: 946305-51-7
- Formula:C21H16N2O5S
- Molecular Weight:408.43
InChIKey: XGLRMCYBRQLWOV-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C(NC2=NC(C3=CC4=C(C=C(C=C4)OC)O3)=CS2)=O)C=C1)OC
Biological Activity: MFT251 is a TBK1 activator. MFT251 directly activates TBK1, increasing kinase activity, IRF3 phosphorylation, and type I interferon and interferon-stimulated gene expression, thereby enhancing macrophage/dendritic cell activation, phagocytosis, and nitric oxide (NO) release, and inhibiting coronavirus replication. MFT251 can be used in research on melanoma and coronavirus infection (including SARS-CoV-2)[1].
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MFT251 | MFT251 is a TBK1 activator. MFT251 directly activates TBK1, increasing kinase activity, IRF3 phosphorylation, and type I interferon and interferon-stimulated gene expression, thereby enhancing macrophage/dendritic cell activation, phagocytosis, and nitric oxide (NO) release, and inhibiting coronavirus replication. MFT251 can be used in research on melanoma and coronavirus infection (including SARS-CoV-2). | |||||||||||||||||||||
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