946619-21-2
946619-21-2
Chemical Structure
MNI137
- CAS No.: 946619-21-2
- Formula:C15H9BrN4O
- Molecular Weight:341.16
IUPAC Name: 4-(8-bromo-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-4-yl)picolinonitrile
InChIKey: KMKZCMKOSAKVGY-UHFFFAOYSA-N
SMILES: N#CC1=NC=CC(C2=NC3=CC=C(Br)C=C3NC(C2)=O)=C1
Biological Activity: MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].
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MNI137 | 95.0% | MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization. | ||||||||||||||||||||
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MNI137 (Standard) | ≥98% | MNI137 (Standard) is the analytical standard of MNI137 (HY-103572). This product is intended for research and analytical applications. MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization. | ||||||||||||||||||||
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