949004-12-0
Chemical Structure
(25S)-Δ7-Dafachronic acid
Synonym(s): Dafachronic acid A; Δ7-Dafachronic acid
- CAS No.: 949004-12-0
- Formula:C27H42O3
- Molecular Weight:414.62
IUPAC Name: (2S,6R)-6-((5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-2,3,4,5,6,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-methylheptanoic acid
InChIKey: SQTAVUCHOVVOFD-OBRBSRNPSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC[C@H](C)C(O)=O)([H])C3=CC[C@](CC(CC4)=O)([H])[C@@]4(C)[C@@]3([H])CC1
Biological Activity: (25S)-Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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(25S)-Δ7-Dafachronic acid | 96.92% | (25S)-Δ7-Dafachronic acid is a ligand and activator of DAF-12 receptor. DAF-12 is a nuclear hormone receptor that regulates larval diapause, developmental age, and adult longevity in Caenorhabditis elegans. | ||||||||||||||||||||
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References
- [1]. null
- [2]. Martin R,et al. Stereoselective synthesis of the hormonally active (25S)-delta7-dafachronic acid, (25S)-Delta4-dafachronic acid, (25S)-dafachronic acid, and (25S)-cholestenoic acid. Org Biomol Chem. 2008 Dec 7;6(23):4293-5.
- [3]. Sharma KK, et al. Synthesis and activity of dafachronic acid ligands for the C. elegans DAF-12 nuclear hormone receptor. Mol Endocrinol. 2009 May;23(5):640-8. [Content Brief]
