95088-49-6
95088-49-6
Chemical Structure
NLS (PKKKRKV)
- CAS No.: 95088-49-6
- Formula:C40H78N14O8
- Molecular Weight:883.14
IUPAC Name: L-prolyl-L-lysyl-L-lysyl-L-lysyl-L-arginyl-L-lysyl-L-valine
InChIKey: HUQAPORYWLIQAO-YYGRSCHNSA-N
SMILES: CC(C)[C@@H](C(O)=O)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H](CCCCN)NC([C@H]1NCCC1)=O)=O)=O)=O)=O)=O
Biological Activity: NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research[1][2][3].
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NLS (PKKKRKV) | 99.03% | NLS (PKKKRKV) is a nuclear localization signal (NLS) derived from the SV40 large T antigen, which mediates the binding of karyophilic proteins to importin α. NLS (PKKKRKV) serves as a method to enhance nuclear entry in the field of gene transfer research. | ||||||||||||||||||||
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References
- [1]. Cao S, et al. Enhanced effect of nuclear localization signal peptide during ultrasound‑targeted microbubble destruction‑mediated gene transfection. Mol Med Rep. 2017;16(1):565-572. [Content Brief]
- [2]. Zanta MA, et al. Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc Natl Acad Sci U S A. 1999;96(1):91-96. [Content Brief]
- [3]. Chai D, et al. Lipid nanoparticles deliver DNA-encoded biologics and induce potent protective immunity. Mol Cancer. 2025;24(1):12. Published 2025 Jan 13. [Content Brief]
