951120-33-5
Chemical Structure
PC190723
- CAS No.: 951120-33-5
- Formula:C14H8ClF2N3O2S
- Molecular Weight:355.75
IUPAC Name: 3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide
InChIKey: INYJNSBDHOVLAH-UHFFFAOYSA-N
SMILES: NC(C1=C(C(OCC2=NC3=C(S2)N=CC(Cl)=C3)=CC=C1F)F)=O
Biological Activity: PC190723 is a bacterial cell division protein FtsZ inhibitor (IC50 = 55 nM). PC 190723 prevents cell division. PC190723 has potent and selective bactericidal activity against staphylococci, including methicillin- and multi-drug-resistant Staphylococcus aureus. PC190723 induces nucleated assembly of Bs-FtsZ into single-stranded coiled protofilaments and polymorphic condensates. PC190723 can be studied in anti-bacterial infection research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PC190723 | 98.67% | PC190723 is a bacterial cell division protein FtsZ inhibitor (IC50 = 55 nM). PC 190723 prevents cell division. PC190723 has potent and selective bactericidal activity against staphylococci, including methicillin- and multi-drug-resistant Staphylococcus aureus. PC190723 induces nucleated assembly of Bs-FtsZ into single-stranded coiled protofilaments and polymorphic condensates. PC190723 can be studied in anti-bacterial infection research. | ||||||||||||||||||||
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References
- [1]. Haydon DJ, et al. An inhibitor of FtsZ with potent and selective anti-staphylococcal activity. Science. 2008 Sep 19;321(5896):1673-5. [Content Brief]
- [2]. Buroni S, et al. The cell division protein FtsZ as a cellular target to hit cystic fibrosis pathogens. Eur J Med Chem. 2020 Mar 15;190:112132. [Content Brief]
- [3]. Andreu JM, et al. The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation. J Biol Chem. 2010 May 7;285(19):14239-46. [Content Brief]
