952474-39-4
952474-39-4
Chemical Structure
PARP1-IN-37
- CAS No.: 952474-39-4
- Formula:C14H11N3O
- Molecular Weight:237.26
SMILES: O=C(N)C1=CC=CC2=CN(N=C21)C3=CC=CC=C3
Biological Activity: PARP1-IN-37 (Compound 8) is an orally active and selective poly(ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitor with an IC50 value of 24 nM for PARP1. PARP1-IN-37 inhibits PARP activity in cells with an EC50 value of 3.7 μM. PARP1-IN-37 is promising for research of BRCA-mutated tumors, such as breast and ovarian cancers[1].
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PARP1-IN-37 | PARP1-IN-37 (Compound 8) is an orally active and selective poly(ADP-ribose) polymerase 1 and 2 (PARP1/2) inhibitor with an IC50 value of 24 nM for PARP1. PARP1-IN-37 inhibits PARP activity in cells with an EC50 value of 3.7 μM. PARP1-IN-37 is promising for research of BRCA-mutated tumors, such as breast and ovarian cancers. | |||||||||||||||||||||
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