955371-84-3
955371-84-3
Chemical Structure
VK-II-86
- CAS No.: 955371-84-3
- Formula:C25H28N2O4
- Molecular Weight:420.50
IUPAC Name: 4-((9H-carbazol-4-yl)oxy)-1-((2-(2-methoxyphenoxy)ethyl)amino)butan-2-ol
InChIKey: OHYHNEODRHJYSS-UHFFFAOYSA-N
SMILES: OC(CCOC1=CC=CC(N2)=C1C3=C2C=CC=C3)CNCCOC4=CC=CC=C4OC
Biological Activity: VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress[1].
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VK-II-86 | 93.33% | VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress. | ||||||||||||||||||||
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3-Hydroxy carvedilol | 3-Hydroxy carvedilol is an active compound. | |||||||||||||||||||||
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Carvedilol metabolite 4-Hydroxyphenyl Carvedilol | 98.42% | 4-Hydroxyphenyl Carvedilol, a metabolite of Carvedilol, is an active metabolite of Carvedilol (HY-B0006) and is produced via CYP2D6-mediated oxidation. | ||||||||||||||||||||
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(S)-Carvedilol (Standard) | ≥98% | (S)-Carvedilol (Standard) is the analytical standard of (S)-Carvedilol. This product is intended for research and analytical applications. | ||||||||||||||||||||
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(R)-Carvedilol | 98.78% | (R)-Carvedilol ((R)-BM 14190) is the orally active R-isomer of Carvedilol (HY-B0006). (R)-Carvedilol has α-receptor blocking activity but no β-receptor blocking activity. (R)-Carvedilol inhibits spontaneous Ca2+ waves. (R)-Carvedilol inhibits stress-induced ventricular tachycardia and delays the development of UV-induced skin tumors and reduces their malignancy. | ||||||||||||||||||||
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Carvedilol (Standard) | 99.92% | Carvedilol (Standard) is the analytical standard of Carvedilol. This product is intended for research and analytical applications. Carvedilol (BM 14190) is a non-selective β/α-1 blocker. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome. | ||||||||||||||||||||
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Carvedilol-d3 | 98.57% | Carvedilol-d3 is the deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome. | ||||||||||||||||||||
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Carvedilol impurity 8 | Carvedilol impurity 8 is an impurity of Carvedilol. | |||||||||||||||||||||
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Carvedilol impurity 6 | Carvedilol impurity 6 (N-Isopropyl carvedilol) is an impurity of Carvedilol. | |||||||||||||||||||||
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O-Desmethylcarvedilol | 97.4% | O-Desmethylcarvedilol (Desmethylcarvedilol) is an active metabolite of the non-selective β-adrenergic receptor (β-AR) antagonist Carvedilol (HY-B0006). O-Desmethylcarvedilol inhibits store-overload-induced calcium release in HEK293 cells expressing the ryanodine receptor 2 (RyR2) R4496C (RyR2R4496C) mutation (IC50 = 7.62 µM). O-Desmethylcarvedilol reduces increases in heart rate and prevents decreases in diastolic blood pressure induced by Isoproterenol (HY-B0468) in conscious rabbits (ED50s = 32 and 5 µg/kg, respectively). | ||||||||||||||||||||
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Carvedilol impurity 11 | Carvedilol impurity 11 is an impurity of Carvedilol. | |||||||||||||||||||||
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