956103-79-0
Chemical Structure
Cochinchinenin C
- CAS No.: 956103-79-0
- Formula:C33H34O7
- Molecular Weight:542.62
IUPAC Name: 3-(4-hydroxy-5-(3-(4-hydroxy-2-methoxyphenyl)-1-(4-methoxyphenyl)propyl)-2-methoxyphenyl)-1-(4-hydroxyphenyl)propan-1-one
InChIKey: SLJWKFROLINAGW-UHFFFAOYSA-N
SMILES: COC(C=C(C=C1)O)=C1CCC(C2=CC=C(C=C2)OC)C3=CC(CCC(C4=CC=C(C=C4)O)=O)=C(C=C3O)OC
Biological Activity: Cochinchinenin C is a GLP-1R agonist that binds to the extracellular domain of the receptor via hydrophobic interactions and hydrogen bonds, and promotes glucose-dependent insulin secretion from pancreatic β-cells. Cochinchinenin C also increases intracellular cAMP and ATP levels. At low concentrations, Cochinchinenin C binds to human serum albumin, alters its microenvironment, and induces dominant static fluorescence quenching. Cochinchinenin C shows almost no cytotoxicity to pancreatic β-cells, and exerts a synergistic effect with Loureirin A (HY-N1505) when binding to human serum albumin. Cochinchinenin C has been widely used in studies of type 2 diabetes, Helicobacter pylori infection, thrombotic diseases, and other conditions[1][2].
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Cochinchinenin C | Cochinchinenin C is a GLP-1R agonist that binds to the extracellular domain of the receptor via hydrophobic interactions and hydrogen bonds, and promotes glucose-dependent insulin secretion from pancreatic β-cells. Cochinchinenin C also increases intracellular cAMP and ATP levels. At low concentrations, Cochinchinenin C binds to human serum albumin, alters its microenvironment, and induces dominant static fluorescence quenching. Cochinchinenin C shows almost no cytotoxicity to pancreatic β-cells, and exerts a synergistic effect with Loureirin A (HY-N1505) when binding to human serum albumin. Cochinchinenin C has been widely used in studies of type 2 diabetes, Helicobacter pylori infection, thrombotic diseases, and other conditions. | |||||||||||||||||||||
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References
- [1]. Sha Y, et al. Cochinchinenin C, a potential nonpolypeptide anti-diabetic drug, targets a glucagon-like peptide-1 receptor[J]. RSC advances, 2017, 7(77): 49015-49023.
- [2]. Chen X, et al. Comparison between loureirin A and cochinchinenin C on the interaction with human serum albumin. Eur J Med Chem. 2015;93:492-500. [Content Brief]
