958001-92-8
958001-92-8
Chemical Structure
Ac-DNLD-AMC
- CAS No.: 958001-92-8
- Formula:C30H38N6O12
- Molecular Weight:674.66
IUPAC Name: (4S,7S,10S,13S)-7-(2-amino-2-oxoethyl)-4-(carboxymethyl)-10-isobutyl-13-((4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl)-2,5,8,11-tetraoxo-3,6,9,12-tetraazapentadecan-15-oic acid
InChIKey: IBRRXVTUFUKLDZ-TUFLPTIASA-N
SMILES: CC(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O)=O)=O)=O)=CC1=O
Biological Activity: Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity[1][2].
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Ac-DNLD-AMC | Ac-WLA-AMC is a fluorogenic substrate of caspase-3. Ac-WLA-AMC is cleaved to release the fluorescent moiety 7-amino-4-methylcoumarin (AMC), which can be used to quantify the β5c subunit activity. | |||||||||||||||||||||
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References
- [1]. Kulikov AV, et al. Targeting mitochondria by α-tocopheryl succinate overcomes hypoxia-mediated tumor cell resistance to treatment. Cell Mol Life Sci. 2014 Jun;71(12):2325-33. [Content Brief]
- [2]. Yoshida K, et al. Caspase-independent cell death without generation of reactive oxygen species in irradiated MOLT-4 human leukemia cells. Cell Immunol. 2009;255(1-2):61-8. [Content Brief]
