958888-13-6
958888-13-6
Chemical Structure
Hsp90-IN-47
- CAS No.: 958888-13-6
- Formula:C17H18N4O3
- Molecular Weight:326.35
InChIKey: SCWLRTVXOJADHE-UHFFFAOYSA-N
SMILES: O=C1NN=C(N1C2=CC=C(C=C2)N)C3=C(O)C=C(O)C(C(C)C)=C3
Biological Activity: Hsp90-IN-47 (Compound C15) is a Hsp90 inhibitor and antifungal agent, with an IC50 of 0.014 μM against Hsp90α. When combined with Fluconazole (HY-B0101), Hsp90-IN-47 exerts significant synergistic antifungal effects against fluconazole-resistant Candida albicans 0304103. Hsp90-IN-47 exhibits antitumor activity against acute myeloid leukemia and non-small cell lung cancer[1].
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Hsp90-IN-47 | Hsp90-IN-47 (Compound C15) is a Hsp90 inhibitor and antifungal agent, with an IC50 of 0.014 μM against Hsp90α. When combined with Fluconazole (HY-B0101), Hsp90-IN-47 exerts significant synergistic antifungal effects against fluconazole-resistant Candida albicans 0304103. Hsp90-IN-47 exhibits antitumor activity against acute myeloid leukemia and non-small cell lung cancer. | |||||||||||||||||||||
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