959687-65-1
959687-65-1
Chemical Structure
(R)-Pioglitazone
Synonym(s): (R)-U 72107
- CAS No.: 959687-65-1
- Formula:C19H20N2O3S
- Molecular Weight:356.44
InChIKey: HYAFETHFCAUJAY-QGZVFWFLSA-N
SMILES: O=C(NC(S1)=O)[C@H]1CC2=CC=C(C=C2)OCCC3=CC=C(C=N3)CC
Biological Activity: (R)-Pioglitazone ((+)-pioglitazone) is the R enantiomer of Pioglitazone (HY-13956). (R)-Pioglitazone is an orally active and selective peroxisome proliferator-activated receptor (PPARγ) agonist with high affinity binding to the PPARγ ligand-binding domain. (R)-Pioglitazone can be used for the research of Alzheimer's disease[1].
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(R)-Pioglitazone | (R)-Pioglitazone ((+)-pioglitazone) is the R enantiomer of Pioglitazone (HY-13956). (R)-Pioglitazone is an orally active and selective peroxisome proliferator-activated receptor (PPARγ) agonist with high affinity binding to the PPARγ ligand-binding domain. (R)-Pioglitazone can be used for the research of Alzheimer's disease. | |||||||||||||||||||||
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(R)-Pioglitazone-d1 | (R)-Pioglitazone-d1 ((R)-U 72107-d1) is a stabilized and deuterated R-enantiomer of pioglitazone, exhibiting pharmacological properties that are beneficial for NASH treatment, including modulation of mitochondrial function, non-steroidal anti-inflammatory effects, and glucose-lowering capabilities. | |||||||||||||||||||||
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References
- [1]. Kuwabara K, et al. A novel selective peroxisome proliferator-activated receptor alpha agonist, 2-methyl-c-5-[4-[5-methyl-2-(4-methylphenyl)-4-oxazolyl]butyl]-1,3-dioxane-r-2-carboxylic acid (NS-220), potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice. J Pharmacol Exp Ther. 2004 Jun;309(3):970-7. [Content Brief]
