959746-77-1
Chemical Structure
A-836339
- CAS No.: 959746-77-1
- Formula:C16H26N2O2S
- Molecular Weight:310.45
IUPAC Name: (Z)-N-(3-(2-methoxyethyl)-4,5-dimethylthiazol-2(3H)-ylidene)-2,2,3,3-tetramethylcyclopropane-1-carboxamide
InChIKey: JKGIMVBQKSRTGX-VKAVYKQESA-N
SMILES: CC1=C(C)S/C(N1CCOC)=N\C(C2C(C)(C)C2(C)C)=O
Biological Activity: A-836339 is a selective CB2 receptor agonist, with Ki values of 0.4 nM and 0.8 nM in humans and rats, respectively. A-836339 exhibits multiple effects such as analgesia, gastric protection, anti-inflammation, and antioxidant activity. A-836339 produces antinociceptive and analgesic activities by activating CB2 receptors in the dorsal root ganglia and spinal cord. A-836339 can also exert gastric protective effects through anti-inflammatory mechanisms (reducing TNF-α and IL-1β) and antioxidant mechanisms (enhancing the activities of CAT and SOD, and reducing H2O2). Radioactively labeled A-836339 can serve as a CB2-specific radioligand for autoradiography and PET imaging. A-836339 can be used in research on inflammatory pain, neuropathic pain, gastric ulcers, cerebral ischemia, etc[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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A-836339 | 99.84% | A-836339 is a selective CB2 receptor agonist, with Ki values of 0.4 nM and 0.8 nM in humans and rats, respectively. A-836339 exhibits multiple effects such as analgesia, gastric protection, anti-inflammation, and antioxidant activity. A-836339 produces antinociceptive and analgesic activities by activating CB2 receptors in the dorsal root ganglia and spinal cord. A-836339 can also exert gastric protective effects through anti-inflammatory mechanisms (reducing TNF-α and IL-1β) and antioxidant mechanisms (enhancing the activities of CAT and SOD, and reducing H2O2). Radioactively labeled A-836339 can serve as a CB2-specific radioligand for autoradiography and PET imaging. A-836339 can be used in research on inflammatory pain, neuropathic pain, gastric ulcers, cerebral ischemia, etc. | ||||||||||||||||||||
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A-836339 (Standard) | ≥98% | A-836339 (Standard) is the analytical standard of A-836339. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Hsieh GC, et al. Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats. Br J Pharmacol. 2011;162(2):428-440. [Content Brief]
- [2]. Simmons TC, et al. Cannabinoid receptor Type 1 densities reflect social organization in Microtus. J Comp Neurol. 2021;529(5):1004-1017. [Content Brief]
- [3]. Salaga M, et al. Highly selective CB2 receptor agonist A836339 has gastroprotective effect on experimentally induced gastric ulcers in mice. Naunyn Schmiedebergs Arch Pharmacol. 2017 Oct;390(10):1015-1027. [Content Brief]
- [4]. Pottier G, et al. PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats. J Cereb Blood Flow Metab. 2017;37(3):1163-1178. [Content Brief]
- [5]. Horti AG, et al. Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2). Bioorg Med Chem. 2010;18(14):5202-5207. [Content Brief]
