96-17-3
Chemical Structure
2-Methylbutanal
Synonym(s): 2-Methylbutyraldehyde
- CAS No.: 96-17-3
- Formula:C5H10O
- Molecular Weight:86.13
IUPAC Name: 2-methylbutanal
InChIKey: BYGQBDHUGHBGMD-UHFFFAOYSA-N
SMILES: CCC(C)C=O
Biological Activity: 2-Methylbutanal (2-Methylbutyraldehyde) is a short-chain aliphatic aldehyde and a characteristic volatile biomarker that can be used to detect the urinary tract pathogen Proteus. 2-Methylbutanal is an orally active CaSR activator and ENO1 inhibitor (Kd = 4.92 μM). 2-Methylbutanal activates oral CaSR to enhance the umami and salty taste of food. 2-Methylbutanal downregulates YAP1 by inhibiting the RNA-binding function of ENO1, thereby upregulating HPGD and reducing PGE2 production, ultimately relieving immunosuppression to promote the infiltration and activation of intratumoral CD8+ T cells. 2-Methylbutanal can be used in research on bacterial infections, colorectal cancer, and food flavor modulation[1][2][3][4][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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2-Methylbutanal | 98.43% | 2-Methylbutanal (2-Methylbutyraldehyde) is a short-chain aliphatic aldehyde and a characteristic volatile biomarker that can be used to detect the urinary tract pathogen Proteus. 2-Methylbutanal is an orally active CaSR activator and ENO1 inhibitor (Kd = 4.92 μM). 2-Methylbutanal activates oral CaSR to enhance the umami and salty taste of food. 2-Methylbutanal downregulates YAP1 by inhibiting the RNA-binding function of ENO1, thereby upregulating HPGD and reducing PGE2 production, ultimately relieving immunosuppression to promote the infiltration and activation of intratumoral CD8+ T cells. 2-Methylbutanal can be used in research on bacterial infections, colorectal cancer, and food flavor modulation. | ||||||||||||||||||||
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References
- [1]. Kitajima S, et al. Volatile Short-Chain Aliphatic Aldehydes Act as Taste Modulators through the Orally Expressed Calcium-Sensing Receptor CaSR. Molecules (Basel, Switzerland). 2023 Jun 06;28(12):4585.
- [2]. Moreira MTG, et al. Aldehyde Accumulation in Aged Alcoholic Beer: Addressing Acetaldehyde Impacts on Upper Aerodigestive Tract Cancer Risks. International journal of molecular sciences. 2022 Nov 16;23(22):14147.
- [3]. Aro R, et al. Endogenous Synthesis of Tetrahydroisoquinoline Derivatives from Dietary Factors: Neurotoxicity Assessment on a 3D Neurosphere Culture. Molecules (Basel, Switzerland). 2022 Nov 02;27(21):7443.
- [4]. Al-Fatimi M. Volatile constituents, et al. from Yemen. J. Pharm. Res. Int. 2018 Jan 1;23(10).
- [5]. Kam S, et al. 2-methylbutanal remodels arachidonic acid metabolism and antitumor immunity through ENO1 in colorectal cancer. Journal of Translational Medicine. 2026 Aug 11.
