960521-38-4
960521-38-4
Chemical Structure
WY-46824
- CAS No.: 960521-38-4
- Formula:C19H29ClN2O
- Molecular Weight:336.90
IUPAC Name: 1-(1-(3-chlorophenyl)-2-(4-methylpiperazin-1-yl)ethyl)cyclohexan-1-ol
InChIKey: GRUIIAQNNWQJPW-UHFFFAOYSA-N
SMILES: ClC1=CC=CC(C(C2(CCCCC2)O)CN3CCN(CC3)C)=C1
Biological Activity: WY-46824 is a selective norepinephrine transporter (NET) inhibitor. WY-46824 does not alter the total expression level or cell surface expression level of hNET. WY-46824 can be used in related research on attention deficit hyperactivity disorder (ADHD)[1][2].
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WY-46824 | WY-46824 is a selective norepinephrine transporter (NET) inhibitor. WY-46824 does not alter the total expression level or cell surface expression level of hNET. WY-46824 can be used in related research on attention deficit hyperactivity disorder (ADHD). | |||||||||||||||||||||
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References
- [1]. Mahaney PE, et al. Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors. Journal of medicinal chemistry. 2008 Jul 10;51(13):4038-49. [Content Brief]
- [2]. Mason JN, et al. Desvenlafaxine succinate identifies novel antagonist binding determinants in the human norepinephrine transporter. The Journal of pharmacology and experimental therapeutics. 2007 Nov;323(2):720-9.
