96201-52-4
96201-52-4
Chemical Structure
S-8660
- CAS No.: 96201-52-4
- Formula:C23H16ClNO2
- Molecular Weight:373.83
IUPAC Name: 2-([1,1'-biphenyl]-4-yl)-5-chloro-3-methylquinoline-4-carboxylic acid
InChIKey: ALBQBKQVMVZCOP-UHFFFAOYSA-N
SMILES: O=C(O)C1=C(C(C2=CC=C(C=C2)C3=CC=CC=C3)=NC4=CC=CC(Cl)=C14)C
Biological Activity: S-8660 is an orally active and selective inhibitor of dihydroorotate dehydrogenase (DHODH). S-8660 is an analog of Brequinar (HY-108325) and exhibits immunosuppressive activity. When combined with Cyclosporin A (HY-B0579), it enhances the effect of prolonging cardiac allograft survival. S-8660 can be used for research on cardiac transplant rejection[1].
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S-8660 | S-8660 is an orally active and selective inhibitor of dihydroorotate dehydrogenase (DHODH). S-8660 is an analog of Brequinar (HY-108325) and exhibits immunosuppressive activity. When combined with Cyclosporin A (HY-B0579), it enhances the effect of prolonging cardiac allograft survival. S-8660 can be used for research on cardiac transplant rejection. | |||||||||||||||||||||
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