96829-59-3
Chemical Structure
Lipstatin
- CAS No.: 96829-59-3
- Formula:C29H49NO5
- Molecular Weight:491.70
IUPAC Name: (S)-(S,4Z,7Z)-1-((2S,3S)-3-hexyl-4-oxooxetan-2-yl)trideca-4,7-dien-2-yl 2-formamido-4-methylpentanoate
InChIKey: OQMAKWGYQLJJIA-CUOOPAIESA-N
SMILES: CC(C)C[C@@H](C(O[C@H](C[C@@H]([C@@H]1CCCCCC)OC1=O)C/C=C\C/C=C\CCCCC)=O)NC=O
Biological Activity: Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Lipstatin | 80.0% | Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Lipstatin (Standard) | ≥98% | Lipstatin (Standard) is the analytical standard of Lipstatin (HY-N2330). This product is intended for research and analytical applications. Lipstatin is a pancreatic lipase inhibitor (IC50=0.14 μM), whose structure is closely related to the known inhibitor, Esterastin. Lipstatin inhibits the absorption of triglycerides without affecting the absorption of oleic acid. Lipstatin has no inhibitory effects on other pancreatic enzymes, such as phospholipase A2 and trypsin (<200 μM). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Hochuli E, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation. J Antibiot (Tokyo). 1987 Aug;40(8):1086-91. [Content Brief]
- [2]. Weibel EK, et al. Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. J Antibiot (Tokyo). 1987 Aug;40(8):1081-5. [Content Brief]
