98224-03-4
98224-03-4
Chemical Structure
Eltoprazine
Synonym(s): DU 28853
- CAS No.: 98224-03-4
- Formula:C12H16N2O2
- Molecular Weight:220.27
IUPAC Name: 1-(2,3-dihydrobenzo[b][1,4]dioxin-5-yl)piperazine
InChIKey: WVLHGCRWEHCIOT-UHFFFAOYSA-N
SMILES: N1(C2=C3OCCOC3=CC=C2)CCNCC1
Biological Activity: Eltoprazine (DU 28853) is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine shows antiaggressive and anxiogenic effects[1][2].
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Eltoprazine | Eltoprazine (DU 28853) is a 5-HT1A/5-HT1B receptors agonist and a 5-HT2C receptor antagonist. Eltoprazine shows antiaggressive and anxiogenic effects. | |||||||||||||||||||||
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References
- [1]. Sijbesma H, et al. Eltoprazine, a drug which reduces aggressive behaviour, binds selectively to 5-HT1 receptor sites in the rat brain: an autoradiographic study. Eur J Pharmacol. 1990 Feb 20;177(1-2):55-66. [Content Brief]
- [2]. Rocha B, et al. Chronic mianserin or eltoprazine treatment in rats: effects on the elevated plus-maze test and on limbic 5-HT2C receptor levels. Eur J Pharmacol. 1994 Sep 1;262(1-2):125-31. [Content Brief]
