98353-69-6
Chemical Structure
Troponin I (104-115)
- CAS No.: 98353-69-6
- Formula:C70H123N27O13
- Molecular Weight:1550.93
IUPAC Name: (S)-1-(acetylglycyl-L-lysyl-L-phenylalanyl-L-lysyl-L-arginyl-L-prolyl)-N-((S)-1-(((S)-1-(((S)-1-(((S)-1-(((S)-1-amino-5-guanidino-1-oxopentan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-5-guanidino-1-oxopentan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)pyrrolidine-2-carboxamide
InChIKey: RIGIYQFULOLFNC-DNCXWKQBSA-N
SMILES: C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@H](CC2=CC=CC=C2)NC([C@@H](NC(CNC(C)=O)=O)CCCCN)=O)=O)CCCCN)=O)CCCNC(=N)N)=O)CCC1)N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)[C@@H](C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)CCC3
Biological Activity: Troponin I (104-115) is a polypeptide derived from Troponin I. Troponin I is an inhibitor of Acto-S1-TM ATPase, with an IC50 of 2.25 μM against skeletal muscle Acto-S1-TM ATP enzyme. Troponin I is used in research on muscle contraction-relaxation and restrictive cardiomyopathy[1][2][3][4].
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Troponin I (104-115) | Troponin I (104-115) is a polypeptide derived from Troponin I. Troponin I is an inhibitor of Acto-S1-TM ATPase, with an IC50 of 2.25 μM against skeletal muscle Acto-S1-TM ATP enzyme. Troponin I is used in research on muscle contraction-relaxation and restrictive cardiomyopathy. | |||||||||||||||||||||
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References
- [1]. Van Eyk JE, et al. The biological importance of each amino acid residue of the troponin I inhibitory sequence 104-115 in the interaction with troponin C and tropomyosin-actin. The Journal of biological chemistry. 1988 Feb 05;263(4):1726-32.
- [2]. Van Eyk JE, et al. A synthetic peptide mimics troponin I function in the calcium-dependent regulation of muscle contraction. FEBS letters. 1993 Jun 01;323(3):223-8.
- [3]. Van Eyk JE, et al. Distinct regions of troponin I regulate Ca2+-dependent activation and Ca2+ sensitivity of the acto-S1-TM ATPase activity of the thin filament. The Journal of biological chemistry. 1997 Apr 18;272(16):10529-37.
- [4]. Huang XP, et al. Troponin I, cardiac diastolic dysfunction and restrictive cardiomyopathy. Acta Pharmacol Sin. 2004 Dec;25(12):1569-75.
