98374-54-0
98374-54-0
Chemical Structure
Siltenzepine
Synonym(s): AWD 26-06 free base
- CAS No.: 98374-54-0
- Formula:C19H20ClN3O4
- Molecular Weight:389.83
IUPAC Name: 5-(bis(2-hydroxyethyl)glycyl)-8-chloro-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one
InChIKey: DDBKYWMANNIJRH-UHFFFAOYSA-N
SMILES: O=C1C2=CC=CC=C2N(C(CN(CCO)CCO)=O)C3=CC=C(Cl)C=C3N1
Biological Activity: Siltenzepine (AWD 26-06 free base) is an antagonist of mAChR with anti-acid activity, which can be used in peptic ulcers research. Siltenzepine exhibits rapidly but incompletely absorbed characterastic in rats (po)[1][2].
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Siltenzepine | Siltenzepine (AWD 26-06 free base) is an antagonist of mAChR with anti-acid activity, which can be used in peptic ulcers research. Siltenzepine exhibits rapidly but incompletely absorbed characterastic in rats (po). | |||||||||||||||||||||
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References
- [1]. Pfeifer S, et al. Biotransformation und Pharmakokinetik von AWD 26-06, 8-Chlor-5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl]-11H- dibenzo[d,c][1,4]diazepin-11-on-hydrochlorid an der Ratte [Biotransformation and pharmacokinetics of AWD 26-06, 8-chloro-5,10-dihydro-5-[bis(2-hydroxyethyl)aminoacetyl]-11H-dibenzo[d, c][1,4]diazepin-11-one hydrochloride in the rat]. Pharmazie. 1990 Jul;45(8):603-7. German. [Content Brief]
- [2]. Trausch B, et al. The biliary and renal elimination of the new muscarinic-1-antagonist AWD 26-06 in volunteers with T-tube after cholecystectomy. Int J Clin Pharmacol Ther Toxicol. 1992 Nov;30(11):508-9. [Content Brief]
