98457-88-6
Chemical Structure
Aminopterin N-hydroxysuccinimide ester
Synonym(s): NHS-Methotrexate
- CAS No.: 98457-88-6
- Formula:C24H27N9O8
- Molecular Weight:569.53
IUPAC Name: 1-hydroxypyrrolidine-2,5-dione (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-L-glutamate
InChIKey: OFZWSRZPXCRNJC-ZOWNYOTGSA-N
SMILES: NC1=NC(N)=NC2=C1N=C(CN(C3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C)C=N2.O=C4N(C(CC4)=O)O
Biological Activity: Aminopterin N-hydroxysuccinimide ester(NHS-methotrexate) is an irreversible Methotrexate (HY-14519) influx carrier inhibitor. Aminopterin N-hydroxysuccinimide ester can be used for the research of rheumatoid arthritis and a number of cancers (such as acute lymphoblastic leukemia)[1][2].
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Aminopterin N-hydroxysuccinimide ester | Aminopterin N-hydroxysuccinimide ester(NHS-methotrexate) is an irreversible Methotrexate (HY-14519) influx carrier inhibitor. Aminopterin N-hydroxysuccinimide ester can be used for the research of rheumatoid arthritis and a number of cancers (such as acute lymphoblastic leukemia). | |||||||||||||||||||||
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References
- [1]. Henderson GB, et al. Characterization of the multiple transport routes for methotrexate in L1210 cells using phthalate as a model anion substrate. J Membr Biol. 1985;85(3):263-268. [Content Brief]
- [2]. Chiao JH, et al. RFC-1 gene expression regulates folate absorption in mouse small intestine. J Biol Chem. 1997;272(17):11165-11170. [Content Brief]
