99207-33-7
99207-33-7
Chemical Structure
MDL 72527 free base
- CAS No.: 99207-33-7
- Formula:C12H20N2
- Molecular Weight:192.30
IUPAC Name: N1,N4-di(buta-2,3-dien-1-yl)butane-1,4-diamine
InChIKey: IKSQCMLJDHRWOA-UHFFFAOYSA-N
SMILES: C=C=CCNCCCCNCC=C=C
Biological Activity: MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects[1][2].
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MDL 72527 free base | MDL 72527 free base is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 free base shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects. | |||||||||||||||||||||
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References
- [1]. Doğan A, et al. Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. J Neurochem. 1999 Feb;72(2):765-70. [Content Brief]
- [2]. Agostinelli E, et al. Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. Biochim Biophys Acta. 2006 Oct;1763(10):1040-50. [Content Brief]
