99465-44-8
Chemical Structure
AFD-21 maleate
- CAS No.: 99465-44-8
- Formula:C28H39NO5
- Molecular Weight:469.61
IUPAC Name: 4-(diisobutylamino)-1,1-diphenylbutan-1-ol maleate
InChIKey: FNQOYOWVZPEOOK-BTJKTKAUSA-N
SMILES: OC(C1=CC=CC=C1)(CCCN(CC(C)C)CC(C)C)C2=CC=CC=C2.O=C(O)/C=C\C(O)=O
Biological Activity: AFD-21 maleate is a drug with antiarrhythmic activity. AFD-21 maleate inhibits sodium channels by binding to sodium channels in an inactive state, with both use-dependent and voltage-dependent effects. The unbinding rate of AFD-21 maleate is similar to that of Class I antiarrhythmic drugs with moderate kinetics. AFD-21 maleate can cause a slight prolongation of the action potential duration and significantly reduce the maximum rise rate of the action potential at certain concentrations. AFD-21 maleate also showed use-dependent blocking effects as stimulation frequency increased[1].
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AFD-21 maleate | AFD-21 maleate is a drug with antiarrhythmic activity. AFD-21 maleate inhibits sodium channels by binding to sodium channels in an inactive state, with both use-dependent and voltage-dependent effects. The unbinding rate of AFD-21 maleate is similar to that of Class I antiarrhythmic drugs with moderate kinetics. AFD-21 maleate can cause a slight prolongation of the action potential duration and significantly reduce the maximum rise rate of the action potential at certain concentrations. AFD-21 maleate also showed use-dependent blocking effects as stimulation frequency increased. | |||||||||||||||||||||
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