99910-50-6
Chemical Structure
4,6-Dibromo indole
- CAS No.: 99910-50-6
- Formula:C8H5Br2N
- Molecular Weight:274.94
IUPAC Name: 4,6-dibromo-1H-indole
InChIKey: PXUDJVIHHHIEGO-UHFFFAOYSA-N
SMILES: C1=CNC2=CC(=CC(=C12)Br)Br
Biological Activity: 4,6-Dibromo indole is a natural product found in the adipose tissue of bottlenose dolphins, algae, and invertebrates including species of the genus Tubastrea, with multiple activities such as nematicidal and antifungal properties. 4,6-Dibromo indole inhibits the motility of Caenorhabditis elegans and induces a multi-stage nematicidal effect. 4,6-Dibromo indole inhibits the growth, biofilm formation, and yeast-hypha transition of Candida, induces ROS accumulation, disrupts hyphal networks, and reduces biofilm biomass. 4,6-Dibromo indole can be used in studies on crop damage related to nematode infestation and Candida infection[1][2][3].
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4,6-Dibromo indole | 4,6-Dibromo indole is a natural product found in the adipose tissue of bottlenose dolphins, algae, and invertebrates including species of the genus Tubastrea, with multiple activities such as nematicidal and antifungal properties. 4,6-Dibromo indole inhibits the motility of Caenorhabditis elegans and induces a multi-stage nematicidal effect. 4,6-Dibromo indole inhibits the growth, biofilm formation, and yeast-hypha transition of Candida, induces ROS accumulation, disrupts hyphal networks, and reduces biofilm biomass. 4,6-Dibromo indole can be used in studies on crop damage related to nematode infestation and Candida infection. | |||||||||||||||||||||
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References
- [1]. Divecha VD, et al. Nematicidal activity of multi-halogenated indoles against Caenorhabditis elegans. Pest management science. 2026 Jun 28.
- [2]. Alonso M B, et al. Nontargeted Screening of Halogenated Organic Compounds in Bottlenose Dolphins (Tursiops truncatus) from Rio de Janeiro, Brazil. Environmental Science & Technology, 2017, 51(3): 1176‑1185.
- [3]. Jeong H, et al. Antifungal Activities of Multi-Halogenated Indoles Against Drug-Resistant Species. International journal of molecular sciences. 2025 Nov 07;26(22):10836.
