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Cat. No.: HY-P3395A

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Catestatin sCst

Catestatin sCst is a scrambled control peptide that serves as a negative control for Catestatin (HY-P1271).

For research use only. We do not sell to patients.

Formula: C₁₀₄H₁₆₄N₃₂O₂₇S
Molecular Weight:2326.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Catestatin sCst Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Catestatin sCst is a scrambled control peptide that serves as a negative control for Catestatin (HY-P1271)^[1]^[2].

In Vitro

Cytokines and ChemokinesOthers

Cytokines and Chemokines

Catestatin sCst (20 μM; 1-6 h) TFA does not stimulate IL-8 mRNA expression in normal human keratinocytes^[2].
Catestatin sCst (20 μM; 24 h) TFA does not stimulate IL-8 protein production from normal human keratinocytes^[2].

Others

Catestatin sCst (1.25 μM) TFA does not induce chemotaxis in normal human keratinocytes^[2].
Catestatin sCst (10 μM; 5 min) TFA does not induce phosphorylation of ERK, p38, or JNK in normal human keratinocytes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[2]

Cell Line:

normal human keratinocytes
Concentration:

20 μM
Incubation Time:

1 h; 3 h; 6 h
Result:

Did not increase IL-8 mRNA expression in normal human keratinocytes, with levels matching those of untreated control cells across all time points tested.

ELISA Assay^[2]

Cell Line:

normal human keratinocytes
Concentration:

20 μM
Incubation Time:

24 h
Result:

Did not induce a significant increase in IL-8 protein production from normal human keratinocytes, with levels remaining comparable to untreated control cells.

Western Blot Analysis^[2]

Cell Line:

normal human keratinocytes
Concentration:

10 μM
Incubation Time:

5 min
Result:

Did not enhance phosphorylation of ERK, p38, or JNK in normal human keratinocytes relative to untreated control cells.

Chemical Information

Molecular Weight 2326.68
Formula C₁₀₄H₁₆₄N₃₂O₂₇S
SMILES

O=C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C)C(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CCCNC(N)=N)C(NCC(N4[C@@H](CCC4)C(NCC(N5[C@@H](CCC5)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCSC)N
Sequence

Met-Lys-Leu-Ser-Ser-Ser-Phe-Arg-Ala-Tyr-Ala-Arg-Gly-Phe-Arg-Gly-Pro-Gly-Pro-Gln-Leu
Sequence Shortening

MKLSSSFRAYARGFRGPGPQL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Hoq MI, et al. Human catestatin enhances migration and proliferation of normal human epidermal keratinocytes. Journal of dermatological science. 2011 Nov;64(2):108-18. [Content Brief]

[2]. Aung G, et al. A neuroendocrine antimicrobial peptide, catestatin, stimulates interleukin-8 production from human keratinocytes via activation of mitogen-activated protein kinases. J Dermatol Sci. 2011 Feb;61(2):142-4.

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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