Cathepsin S, human
Based on 2 publication(s) in Google Scholar
Human Cathepsin S (CTSS) is a cysteine protease with elastinolytic activity. Human Cathepsin S is inhibited by cysteine protease inhibitors such as E-64 (HY-15282) and cystatin C. Human Cathepsin S cleaves substrates including elastin, TGF-β1, Myelin basic protein (HY-P1821), PAR2, SIRT1, collagen 18A1, FKN, and MHC-II invariant chain fragments, thereby driving processes such as elastic matrix degradation, TGF-β1 signaling, demyelination, PAR2-mediated calcium mobilization, NF-κB activation, hepatic fibrosis, immune homeostasis regulation, and antigen presentation. Human Cathepsin S can be used in the research of cardiovascular diseases, chronic kidney diseases, autoimmune diseases, tumors, Alzheimer's disease, and obesity.
For research use only. We do not sell to patients.
- CAS No.: 71965-46-3
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Cathepsin S, human
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Biological Activity
Description
In Vitro
Cathepsin S, human promotes NF-κB-dependent inflammatory responses in the liver by degrading SIRT1, whereas inhibition of CTSS stabilizes SIRT1 and thereby suppresses NF-κB in human hepatocytes[1].
Cathepsin S, human (24 h) efficiently degrades the Ii-p10 and Ii-p22 fragments, and reduces the accumulation of lysosomal Ii chains in HeLa-CIITA cells[5].
Cathepsin S, human (24 h) effectively degrades the Ii-p10 fragment and reduces the accumulation of lysosomal Ii chains in MelJuSo cells, whereas the degradation of Ii-p22 in these cells does not require Cathepsin S[5].
Cathepsin S, human cleaves secretory leukocyte protease inhibitor in vitro[3].
Cathepsin S, human degrades defensins in vitro[3].
Cathepsin S, human degrades surfactant protein A in vitro[3].
Cathepsin S, human proteolytically processes Amiloride (HY-B0285)-sensitive epithelial sodium channels in vitro[3].
Cathepsin S, human releases the pro-angiogenic γ2 peptide from laminin-5 in vitro[3].
Cathepsin S, human releases endostatin from type XVII collagen in vitro[3].
Cathepsin S, human (0.4 μM; 2 h) potently degrades the Ii-p10 fragment in the cell membrane of HeLa-CIITA cells, whereas human cathepsin L fails to effectively degrade Ii-p10 even at a concentration 10 times higher[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
- Invadopodia/Fluorescent Gelatin Degradation Assay
- Fibrosis/Collagen Morphometry
- Collagen: Sirius Red Staining
- Connective Tissue: Masson's Trichrome/Collagen Trichrome Staining
- Fibers: Elastic Fiber Staining
- Research Protocol for Inflammation-related Diseases
- Research Protocol for Metabolic Diseases
- Alzheimer’s Disease Modeling
Chemical Information
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CAS No. 71965-46-3
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Cathepsin S, human]
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Synonyms
CTSS
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Shipping
Shipping with dry ice.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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Sci Adv
Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker. [Abstract]2025 Apr 4;11(14):eadr5541. PMID: 40173246 -
Chem Asian J
2025 Aug;20(15):e01719. PMID: 40401741
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Gao H, et al. Cathepsin S: molecular mechanisms in inflammatory and immunological processes. Frontiers in immunology. 2025;16:1600206. [Content Brief]
[3]. Wilkinson RD, et al. Cathepsin S: therapeutic, diagnostic, and prognostic potential. Biological chemistry. 2015 Aug;396(8):867-82. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cathepsin S, human Related Classifications
HY-E70226 Related Classifications
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