cBu-Cit-GAL-02-221
Based on 1 Customer Validation
For research use only. We do not sell to patients.
- Purity : 98.65%
- CAS No.: 2417369-73-2
- Formula: C79H99ClN16O16S2
- Molecular Weight:1628.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
The DAR 5.7 STEAP1−3a-D6 PAC constructed from cBu-Cit-GAL-02-221 degrades BRD4 in PC3-S1 cells after 72 h of treatment. Its absolute DC50 value is 0.21 μg/mL, the DC50 calculated on a payload equivalent basis is 7.9 nM, and the maximum reduction level of BRD4 reaches 70%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2417369-73-2
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Appearance Solid
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Molecular Weight 1628.31
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Formula C79H99ClN16O16S2
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Color White to off-white
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SMILES
CC1=C(C)SC(N2C3=NN=C2C)=C1C(C4=CC=C(C=C4)Cl)=N[C@H]3CC(NCCOCCOCCOCC(N[C@H](C(N5C[C@@H](C[C@H]5C(NCC(C=C6)=CC=C6C7=C(C)N=CS7)=O)OCNC(OCC8=CC=C(NC([C@@H](NC(C9(C(NCCCCCN%10C(C=CC%10=O)=O)=O)CCC9)=O)CCCNC(N)=O)=O)C=C8)=O)=O)C(C)(C)C)=O)=O
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Synonyms
cBu-Cit-PROTAC BRD4 Degrader-5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : ≥ 100 mg/mL (61.41 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6141 mL | 3.0707 mL | 6.1413 mL | 15.3533 mL |
| 5 mM | 0.1228 mL | 0.6141 mL | 1.2283 mL | 3.0707 mL | |
| 10 mM | 0.0614 mL | 0.3071 mL | 0.6141 mL | 1.5353 mL | |
| 15 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 1.0236 mL | |
| 20 mM | 0.0307 mL | 0.1535 mL | 0.3071 mL | 0.7677 mL | |
| 25 mM | 0.0246 mL | 0.1228 mL | 0.2457 mL | 0.6141 mL | |
| 30 mM | 0.0205 mL | 0.1024 mL | 0.2047 mL | 0.5118 mL | |
| 40 mM | 0.0154 mL | 0.0768 mL | 0.1535 mL | 0.3838 mL | |
| 50 mM | 0.0123 mL | 0.0614 mL | 0.1228 mL | 0.3071 mL | |
| 60 mM | 0.0102 mL | 0.0512 mL | 0.1024 mL | 0.2559 mL |
cBu-Cit-GAL-02-221 Related Classifications
HY-160694 Related Classifications
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