CDK12/13 ligand 4
CDK12/13 ligand 4 is a CDK12/13 ligand that can be used for the synthesis of PROTACs, such as PROTAC CDK12/13 Degrader-1 (HY-151110).
For research use only. We do not sell to patients.
- Formula: C30H35N7O
- Molecular Weight:509.65
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CDK12 |
CDK13 |
Chemical Information
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Appearance Solid
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Molecular Weight 509.65
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Formula C30H35N7O
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SMILES
O=C(NCC1=CC=CC=C1)N([C@H]2CC[C@H](NC3=NC=C(C#N)C=C3)CC2)C4=CC=C(N5CCNCC5)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (196.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9621 mL | 9.8107 mL | 19.6213 mL | 49.0533 mL |
| 5 mM | 0.3924 mL | 1.9621 mL | 3.9243 mL | 9.8107 mL | |
| 10 mM | 0.1962 mL | 0.9811 mL | 1.9621 mL | 4.9053 mL | |
| 15 mM | 0.1308 mL | 0.6540 mL | 1.3081 mL | 3.2702 mL | |
| 20 mM | 0.0981 mL | 0.4905 mL | 0.9811 mL | 2.4527 mL | |
| 25 mM | 0.0785 mL | 0.3924 mL | 0.7849 mL | 1.9621 mL | |
| 30 mM | 0.0654 mL | 0.3270 mL | 0.6540 mL | 1.6351 mL | |
| 40 mM | 0.0491 mL | 0.2453 mL | 0.4905 mL | 1.2263 mL | |
| 50 mM | 0.0392 mL | 0.1962 mL | 0.3924 mL | 0.9811 mL | |
| 60 mM | 0.0327 mL | 0.1635 mL | 0.3270 mL | 0.8176 mL | |
| 80 mM | 0.0245 mL | 0.1226 mL | 0.2453 mL | 0.6132 mL | |
| 100 mM | 0.0196 mL | 0.0981 mL | 0.1962 mL | 0.4905 mL |
CDK12/13 ligand 4 Related Classifications
HY-48507 Related Classifications
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