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Cat. No.: HY-162528

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CDK12-IN-7

CDK12-IN-7 (Compound 2) is a CDK12 and CDK2 inhibitor with IC₅₀ values of 42 and 196 nM, respectively. CDK12-IN-7 has anti-cell proliferation activity and can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 3033863-94-1
Formula: C₃₂H₃₂F₃N₉O₄
Molecular Weight:663.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

CDK12-IN-7 Chemical Structure

CAS No.: 3033863-94-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

CDK2

196 nM (IC₅₀)

CDK12

42 nM (IC₅₀)

All CDK Isoforms :

In Vitro

CDK12-IN-7 inhibits A2780 cell proliferation with an IC₅₀ value of 429 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3033863-94-1
Molecular Weight 663.65
Formula C₃₂H₃₂F₃N₉O₄
SMILES

O=C(NCC1=CC=CC=C1)N(C2=CC=C(N(C=CC(N3C)=O)C3=N4)C4=N2)[C@H](CC5)CC[C@@H]5NC6=NC(OC7COC7)=C(C(F)(F)F)C=N6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hu pu, et al. Tricyclic derivative, pharmaceutical composition and use.WO2024066984A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CDK12-IN-7

All CDK Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CDK12-IN-7 Related Classifications

HY-162528 Related Classifications

Bioz

Keywords

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