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Cat. No.: HY-184884

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CDK2-IN-61

CDK2-IN-61 is a highly selective CDK2 inhibitor with a human IC₅₀ of 0.25 nM. CDK2-IN-61 can be used in cancer-related research.

For research use only. We do not sell to patients.

CAS No.: 2498658-20-9
Formula: C₂₁H₂₅N₅O₄S
Molecular Weight:443.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CDK2-IN-61 Chemical Structure

CAS No.: 2498658-20-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

CDK2-IN-61 is a highly selective CDK2 inhibitor with a human IC₅₀ of 0.25 nM. CDK2-IN-61 can be used in cancer-related research^[1].

IC₅₀ & Target

^[1]

CDK2/cyclinE

0.25 nM (IC₅₀)

All CDK Isoforms :

In Vitro

Cell Cycle RegulationOthers

Cell Cycle Regulation

CDK2-IN-61 (compound 4g) exhibits inhibitory activity against CDK2/cyclin E1 with an IC₅₀ value of 0.25 nM, and shows 1200-fold, 1000-fold, and 230-fold selectivity over CDK1/cyclin B1, CDK4/cyclin D1, and CDK6/cyclin D1, respectively^[1].

Others

CDK2-IN-61 exhibits a potency of 670 nM in in vitro human whole blood assays; it shows excellent kinome-wide selectivity in a cell-free kinome screening panel containing 54 kinases; and it displays a clearance rate of 0.8 L/h/kg in cell-free human liver microsome assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2498658-20-9
Molecular Weight 443.52
Formula C₂₁H₂₅N₅O₄S
SMILES

O=C1C2(CC2)C3=CN=C(NC4=CC=C(C=C4)S(NC)(=O)=O)N=C3N1[C@H]5C[C@@H](CCC5)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sokolsky A, et al. Discovery of 5,7-Dihydro-6-pyrrolo[2,3-]pyrimidin-6-ones as Highly Selective CDK2 Inhibitors. ACS medicinal chemistry letters. 2022 Nov 10;13(11):1797-1804. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CDK2-IN-61

All CDK Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CDK2-IN-61 Related Classifications

HY-184884 Related Classifications

Bioz

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