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Cat. No.: HY-162530

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CDK4/6-IN-20

CDK4/6-IN-20 (Compound II-5) is a CDK4/CDK6 inhibitor with IC₅₀ values of 1.9, 14.2 nM, respectively. CDK4/6-IN-20 also inhibits cell proliferation and can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 3033950-84-1
Formula: C₂₃H₂₄FN₅O₂
Molecular Weight:421.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CDK4/6-IN-20 Chemical Structure

CAS No.: 3033950-84-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

CDK4/6-IN-20 (Compound II-5) is a CDK4/CDK6 inhibitor with IC₅₀ values of 1.9, 14.2 nM, respectively. CDK4/6-IN-20 also inhibits cell proliferation and can be used in cancer research^[1].

IC₅₀ & Target

CDK4

1.9 nM (IC₅₀)

CDK6

14.2 nM (IC₅₀)

All CDK Isoforms :

In Vitro

CDK4/6-IN-20 inhibits the proliferation of MCF7 and T47D cells with IC₅₀ values of 169 and 92 nM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3033950-84-1
Molecular Weight 421.47
Formula C₂₃H₂₄FN₅O₂
SMILES

O[C@@H]1COCC[C@H]1NC2=NC=C(C#N)C(C3=CC(C4(CCCC4)C(C)=N5)=C5C(F)=C3)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. HU, Pu, et al. 2-aminopyrimidine compound, and use and pharmaceutical composition thereof.WO2024066986A1.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CDK4/6-IN-20

All CDK Isoforms

Biological Activity

Description

IC50 & Target

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CDK4/6-IN-20 Related Classifications

HY-162530 Related Classifications

Bioz

Keywords

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