Ceftaroline chloride hydrochloride
Based on 1 publication(s) in Google Scholar
Ceftaroline chloride hydrochloride (T-91825 chloride hydrochloride) is a cephalosporin compound and the active form of Ceftaroline fosamil (HY-14737). Ceftaroline chloride hydrochloride exhibits activity against Gram-positive bacteria, Gram-negative bacteria, and some anaerobic bacteria. Ceftaroline chloride hydrochloride binds to penicillin-binding proteins 2 and 2A, thereby inhibiting the synthesis of bacterial peptidoglycan and cell wall, and acts as a bactericide, synergist, and resistance inhibitor. Ceftaroline chloride hydrochloride can be used in research related to complicated skin and soft tissue infections, community-acquired pneumonia, Enterococcus faecalis infective endocarditis, and bacterial infections.
For research use only. We do not sell to patients.
- CAS No.: 614758-10-0
- Formula: C22H22Cl2N8O5S4
- Molecular Weight:677.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Ceftaroline chloride hydrochloride
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Biological Activity
Description
In Vitro
Ceftaroline (6-24 h) chloride hydrochloride exhibits rapid, potent bactericidal activity against MRSA strains OFU4 and TY6242 at concentrations of 2 MIC and higher, reducing viable cell counts significantly over 24 h[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Ceftaroline chloride hydrochloride, delivered via its prodrug TAK-599 (20 mg/kg; s.c.; three times daily; starting 2 hours post infection or day 1 and day 2 post infection), significantly reduces MRSA bacterial counts in the lungs of neutropenic mice, even when treatment is initiated at a late stage of infection[4].
Ceftaroline chloride hydrochloride, delivered via its prodrug TAK-599 (20 mg/kg; s.c.; three doses; at 2, 20, and 26 hours post infection), reduces MRSA bacterial counts in mouse thigh muscle to 0.1% or less of control levels[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:ICR mice (4-week-old male; systemic MRSA infection model via intraperitoneal MRSA injection in 5% mucin)[4]
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Dosage:1.08 mg/kg (strain TY5826); 1.46 mg/kg (strain TY6007); 4.81 mg/kg (strain TY5993); 2.09 mg/kg (strain TY6242)
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Administration:s.c.; single dose; 1 hour post bacterial challenge
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Result:Achieved ED50 of 1.08 mg/kg for protection against systemic MRSA infection (strain TY5826).
Achieved ED50 of 1.46 mg/kg for protection against systemic MRSA infection (strain TY6007).
Achieved ED50 of 4.81 mg/kg for protection against systemic MRSA infection (strain TY5993).
Achieved ED50 of 2.09 mg/kg for protection against systemic MRSA infection (strain TY6242).
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Animal Model:CBA/J mice (5-week-old female; neutropenic MRSA pneumonia model via intranasal MRSA inoculation, neutropenia induced by intraperitoneal cyclophosphamide 4 days and 1 day pre-infection)[4]
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Dosage:20 mg/kg
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Administration:s.c.; three times daily; starting 2 hours post infection or day 1 and day 2 post infection
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Result:Reduced lung bacterial counts by more than 99.9% compared to untreated day 3 controls when treatment started on day 1 after infection.
Reduced lung bacterial counts to 1/100 the level of day 1 controls when treatment started on day 1 after infection.
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Animal Model:ICR mice (4-week-old male; MRSA thigh muscle infection model via intramuscular MRSA injection in left thigh)[4]
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Dosage:20 mg/kg
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Administration:s.c.; three doses; at 2, 20, and 26 hours post infection
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Result:Reduced thigh muscle bacterial counts to 0.1% or less of untreated control levels.
Chemical Information
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CAS No. 614758-10-0
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Molecular Weight 677.63
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Formula C22H22Cl2N8O5S4
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SMILES
OC(C1=C(SC2=NC(C3=CC=[N+](C)C=C3)=CS2)CS[C@@]([C@@H]4NC(/C(C5=NSC(N)=N5)=N\OCC)=O)([H])N1C4=O)=O.[Cl-].Cl
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Synonyms
T-91825 chloride hydrochloride; PPI-0903M chloride hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Infect Dis
Enhanced Killing of Methicillin-Resistant Staphylococcus aureus With Ceftaroline or Vancomycin in Combination With Carbapenems. [Abstract]2025 Jul 30;232(1):181-190. PMID: 39777519
Purity & Documentation
References
[3]. Sader HS, et al. Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains. Antimicrobial agents and chemotherapy. 2005 Aug;49(8):3501-12. [Content Brief]
[4]. Iizawa Y, et al. In vitro antimicrobial activity of T-91825, a novel anti-MRSA cephalosporin, and in vivo anti-MRSA activity of its prodrug, TAK-599. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2004 Jun;10(3):146-56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ceftaroline chloride hydrochloride Related Classifications
HY-105049B Related Classifications
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Keywords
- Ceftaroline chloride
- 614758-10-0
- T-91825 chloride
- PPI-0903M chloride
- Bacterial
- Antibiotic
- Penicillin-binding protein (PBP)
- gram-negative bacteria
- MRSA
- gram-positive bacteria
- Enterococcus faecalis
- community-acquired pneumonia
- penicillin-binding proteins 2A
- penicillin-binding proteins 2
- complicated skin and soft tissue infections
- bacterial peptidoglycan
- anaerobic bacteria
- Inhibitor
- inhibitor
- inhibit