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Cat. No.: HY-19655S

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Cethromycin-d₆

Name: Cethromycin-d6
Brand: MedChemExpress
SKU: HY-19655S
Price: 610.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ABT-773-d₆; Abbott-195773-d₆; A-195773-d₆)

Customer Review

Based on 1 Customer Validation

Cethromycin-d₆ (ABT-773-d₆; Abbott-195773-d₆; A-195773-d₆) is the d₆-labeled Cethromycin (HY-19655). Cethromycin (ABT-773; Abbott-195773) is an orally effective ketolide antibiotic with broad-spectrum antibacterial activity. Cethromycin binds to domains II/V of the 23S rRNA of the 50S subunit, inhibiting bacterial protein synthesis. Cethromycin can accumulate in lung tissue, alveolar macrophages, epithelial lining fluid, and human polymorphonuclear leukocytes. Cethromycin exhibits potent in vitro activity against a variety of respiratory pathogens, including Mycoplasma pneumoniae. Cethromycin exhibits significant intracellular and pulmonary enrichment and anti-inflammatory effects against mycoplasma pneumonia in mouse models, improving airway obstruction and airway hyperresponsiveness. Cethromycin disrupts the apicoplast and reduces liver-stage parasite burden during the liver stage of Plasmodium berghei. Cethromycin can be used in research related to pneumonia, Staphylococcus aureus infection, gonorrhea, and malaria.

For research use only. We do not sell to patients.

Purity : 96.10%
Formula: C₄₂H₅₃D₆N₃O₁₀
Molecular Weight:771.97

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Cethromycin-d₆ Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Biological Activity

Description

All Antibiotic Isoforms :

All Parasite Isoforms :

All TNF Receptor Isoforms :

All Interleukin Related Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 205110-48-1
Appearance Solid
Molecular Weight 771.97
Formula C₄₂H₅₃D₆N₃O₁₀
Color White to off-white
SMILES

O[C@H]1[C@@](O[C@@H]([C@@](OC/C=C\C2=C([2H])C(C([2H])=C([2H])C([2H])=C3[2H])=C3N=C2[2H])(C)C[C@@H](C)C4=O)[C@@H](C)C([C@@H](C)C(O[C@H](CC)[C@](OC(N5)=O)(C)[C@@]5([H])[C@H]4C)=O)=O)([H])O[C@H](C)C[C@@H]1N(C)C
Synonyms

ABT-773-d₆; Abbott-195773-d₆; A-195773-d₆
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hammerschlag MR, et al. Use of cethromycin, a new ketolide, for treatment of community-acquired respiratory infections. Expert opinion on investigational drugs. 2008 Mar;17(3):387-400.

[2]. Pavlović D, et al. Discovery of 4''-ether linked azithromycin-quinolone hybrid series: influence of the central linker on the antibacterial activity. ACS medicinal chemistry letters. 2011 May 12;2(5):331-6.

[3]. Sullivan DJ, et al. Discovery of Novel Liver-Stage Antimalarials through Quantum Similarity. PLoS One. 2015 May 7;10(5):e0125593.

[4]. Bosnar M, et al. Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin. Antimicrobial agents and chemotherapy. 2005 Jun;49(6):2372-7.

[5]. Parnham MJ. Immunomodulatory effects of antimicrobials in the therapy of respiratory tract infections. Curr Opin Infect Dis. 2005 Apr;18(2):125-31.

[6]. Kim MK, et al. Bactericidal effect and pharmacodynamics of cethromycin (ABT-773) in a murine pneumococcal pneumonia model. Antimicrobial agents and chemotherapy. 2002 Oct;46(10):3185-92.

[7]. Hu Y, et al. The antimicrobial activity of cethromycin against Staphylococcus aureus and compared with erythromycin and telithromycin. BMC microbiology. 2023 Apr 20;23(1):109. [Content Brief]

[8]. Kennedy G, et al. Cethromycin pharmacokinetics and pharmacodynamics for single dose cure of Plasmodium berghei liver stages. Antimicrob Agents Chemother. 2025 Aug 6;69(8):e0021525.

[9]. Ríos AM, et al. Impact of cethromycin (ABT-773) therapy on microbiological, histologic, immunologic, and respiratory indices in a murine model of Mycoplasma pneumoniae lower respiratory infection. Antimicrobial agents and chemotherapy. 2004 Aug;48(8):2897-904.

[10]. Xuan D, et al. Pharmacokinetics of ABT-773, a new semi-synthetic ketolide in neutropenic lung-infected mice: a population approach. J Pharm Pharmacol. 2002 Jan;54(1):71-5.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Cethromycin-d₆

All Antibiotic Isoforms

All Parasite Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

Biological Activity

Description

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Bioz

Keywords

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Cethromycin-d6

All Antibiotic Isoforms

All Parasite Isoforms

All TNF Receptor Isoforms

All Interleukin Related Isoforms

Biological Activity

Description

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Cethromycin-d6 Related Classifications

HY-19655S Related Classifications

Bioz

Keywords

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Cethromycin-d₆

Cethromycin-d₆ Related Classifications