Chlorophyll b
Based on 1 Customer Validation
Chlorophyll b is an orally active tetrapyrrole derivative and pigment. Chlorophyll b can be obtained from photosynthetic organisms such as plants and algae. Chlorophyll b acts as a hydrogen donor and increases Glutathione levels. Chlorophyll b has antioxidant activity and functionally replaces chlorophyll a in photosystem II to participate in photosynthesis. Chlorophyll b reduces Cisplatin (HY-17394)-induced DNA damage, chromosome instability, and oxidative stress. Chlorophyll b is mainly used in the study of plant photosynthesis mechanism.
For research use only. We do not sell to patients.
- Purity : 97.46%
- CAS No.: 519-62-0
- Formula: C55H70MgN4O6
- Molecular Weight:907.47
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
Chlorophyll b can serve as the major pigment in functional photosystem II complexes of cyanobacteria when introduced into a photosystem I-less strain of Synechocystis sp. PCC 6803 along with lhcb encoding light-harvesting complex (LHC)II from pea[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Chlorophyll b (0.5 mg/kg; gavage; daily; 13 days) combined with lutein shows antigenotoxic and antimutagenic effects as well as prevents Cisplatin-induced GSH depletion in peripheral blood cells in mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female and male albino Swiss mice (Mus musculus) (both genders, approximately 30 g, 7-8 weeks old)[3]
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Dosage:0.5 mg/kg body weight
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Administration:Administered daily by gavage for 13 consecutive days
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Result:Presented antigenotoxic and antimutagenic effects in different cell types of mice, such as peripheral blood, bone marrow, liver, and kidney cells.
Prevented the glutathione depletion induced by cisplatin in peripheral blood cells, maintaining the glutathione concentration at a level similar to the control group.
Had no significant effect on catalase activity.
Chemical Information
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CAS No. 519-62-0
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Appearance Solid
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Molecular Weight 907.47
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Formula C55H70MgN4O6
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Color Green to dark green
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SMILES
CC1=C2[N-]3[Mg+2]45[N]6=C(C=C7[N-]4C(C(C=C)=C7C)=CC8=[N]5C(C(CC)=C8C=O)=C2)[C@@H](C)[C@H](CCC(OC/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=O)C6=C9C3=C1C([C@@H]9C(OC)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
Ethanol : 10 mg/mL (11.02 mM; Need ultrasonic and warming)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
[1]. Xu H, et al. Chlorophyll b can serve as the major pigment in functional photosystem II complexes of cyanobacteria. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):14168-73. [Content Brief]
[2]. Serpeloni JM, et al. An evaluation, using the comet assay and the micronucleus test, of the antigenotoxic effects of chlorophyll b in mice. Mutat Res. 2011 Oct 9;725(1-2):50-6. [Content Brief]
[3]. Serpeloni JM, et al. Effects of lutein and chlorophyll b on GSH depletion and DNA damage induced by cisplatin in vivo. Hum Exp Toxicol. 2013 Aug;32(8):828-36. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.1020 mL | 5.5098 mL | 11.0196 mL | 27.5491 mL |
| 5 mM | 0.2204 mL | 1.1020 mL | 2.2039 mL | 5.5098 mL | |
| 10 mM | 0.1102 mL | 0.5510 mL | 1.1020 mL | 2.7549 mL |
Chlorophyll b Related Classifications
HY-W127709 Related Classifications
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